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42 results found

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

Publication: Journal Article

Thum, Thomas, Carina Gross, Jan Fiedler, Thomas Fischer, Stephan Kissler, Markus Bussen, Paolo Galuppo, et al. 2008. “MicroRNA-21 Contributes to Myocardial Disease by Stimulating MAP Kinase Signalling in Fibroblasts”. Nature 456 (7224): 980-4.

Collective Cancer Invasion Forms an Integrin-Dependent Radioresistant Niche

Publication: Journal Article

A, Haeger, Alexander S, . , Kissler S, and Friedl P. 2020. “Collective Cancer Invasion Forms an Integrin-Dependent Radioresistant Niche”. J Exp Med 217 (1).

Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes

Publication: Journal Article

Cai, EP, Ishikawa, Zhang, NC Leite, Li, Hou, Kiaf, et al. 2020. “Genome-Scale in Vivo CRISPR Screen Identifies RNLS As a Target for Beta Cell Protection in Type 1 Diabetes”. Nature Metabolism 2 (9): 934-45.

IMMUN201 Workshop - The Why and How of genetically manipulated mice

Class

This one and a half hour workshop is part of the IMMUN201 course and covers the history of genetic engineering in mice, the latest methods and their application. The workshop includes an excercise in designing new genetically modified models to answer a specific question related to immune function.

Lab members

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Current members Stephan Kissler, PhD – Principal Investigator Tara Macdonald, PhD - Postdoctoral fellow Kevin Bode, PhD - Postdoctoral fellow Celia Vived, PhD - Postdoctoral fellow Gabriela Ramirez, PhD - Postdoctoral fellow Bryhan Mendez - Research Assistant Past members Postdoctoral Fellows Badr...

Ptpn22 Modifies Regulatory T Cell Homeostasis via GITR Upregulation

Publication: Journal Article

Nowakowska, Dominika, and Stephan Kissler. 2016. “Ptpn22 Modifies Regulatory T Cell Homeostasis via GITR Upregulation”. J Immunol 196 (5): 2145-52.

Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice

Publication: Journal Article

Chaudhari, Sweena, Judith Sluimer, Miriam Koch, Thomas Theelen, Helga Manthey, Martin Busch, Celia Caballero-Franco, et al. 2015. “Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice”. Arterioscler Thromb Vasc Biol 35 (11): 2316-25.

The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection

Publication: Journal Article

Schuster, Cornelia, Kay Gerold, Kilian Schober, Lilli Probst, Kevin Boerner, Mi-Jeong Kim, Anna Ruckdeschel, Thomas Serwold, and Stephan Kissler. 2015. “The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection”. Immunity 42 (5): 942-52.

IL-17 silencing does not protect nonobese diabetic mice from autoimmune diabetes

Publication: Journal Article

Joseph, Julie, Stefan Bittner, Fabian Kaiser, Heinz Wiendl, and Stephan Kissler. 2012. “IL-17 Silencing Does Not Protect Nonobese Diabetic Mice from Autoimmune Diabetes”. J Immunol 188 (1): 216-21.

STIM1-independent T cell development and effector function in vivo

Publication: Journal Article

Beyersdorf, Niklas, Attila Braun, Timo Vögtle, David Varga-Szabo, Ronmy Rivera Galdos, Stephan Kissler, Thomas Kerkau, and Bernhard Nieswandt. 2009. “STIM1-Independent T Cell Development and Effector Function in Vivo”. J Immunol 182 (6): 3390-7.