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Research Focus
The overarching goals of the lab are to accelerate the identification of novel therapeutic targets for human diseases by leveraging chemical biology tools and multi-omic human datasets.
Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis
Kimberly, Taylor, John O’Sullivan, Anjali Nath, Michelle Keyes, Xu Shi, Martin Larson, Qiong Yang, et al. 2017. “Metabolite Profiling Identifies Anandamide As a Biomarker of Nonalcoholic Steatohepatitis”. JCI Insight 2 (9).
Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades
Nath, Anjali, Rachel Brown, Michael Michaud, Rocio Sierra-Honigmann, Michael Snyder, and Joseph Madri. 2008. “Leptin Affects Endocardial Cushion Formation by Modulating EMT and Migration via Akt Signaling Cascades”. J Cell Biol 181 (2): 367-80.
Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy
Nath, Anjali, Josephine Enciso, Misako Kuniyasu, Xiao-Ying Hao, Joseph Madri, and Emese Pinter. 2004. “Nitric Oxide Modulates Murine Yolk Sac Vasculogenesis and Rescues Glucose Induced Vasculopathy”. Development 131 (10): 2485-96.
Elevation of vitreous leptin in diabetic retinopathy and retinal detachment
Gariano, Nath, D’Amico, Lee, and Sierra-Honigmann. 2000. “Elevation of Vitreous Leptin in Diabetic Retinopathy and Retinal Detachment”. Invest Ophthalmol Vis Sci 41 (11): 3576-81.
Control of apoptosis during angiogenesis by survivin expression in endothelial cells
O’Connor, Schechner, Adida, Mesri, Rothermel, Li, Nath, Pober, and Altieri. 2000. “Control of Apoptosis During Angiogenesis by Survivin Expression in Endothelial Cells”. Am J Pathol 156 (2): 393-8.
Biological action of leptin as an angiogenic factor
Sierra-Honigmann, Nath, Murakami, García-Cardeña, Papapetropoulos, Sessa, Madge, et al. 1998. “Biological Action of Leptin As an Angiogenic Factor”. Science 281 (5383): 1683-6.
Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization
Bale, Tracy, Frank Giordano, Reed Hickey, Yan Huang, Anjali Nath, Kirk Peterson, Wylie Vale, and Kuo-Fen Lee. 2002. “Corticotropin-Releasing Factor Receptor 2 Is a Tonic Suppressor of Vascularization”. Proc Natl Acad Sci U S A 99 (11): 7734-9.
Patterns and Predictors of Weight Loss with Exenatide Treatment in Overweight and Obese Women
Dushay, Jody, Eleftheria Maratos Flier, Robert Gerzsten, Megan Rodgers, Brent Heineman, Alexandra Migdal, Natasha Kasid, et al. 2020. “Patterns and Predictors of Weight Loss With Exenatide Treatment in Overweight and Obese Women”. MedRxiv.