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Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

Publication: Journal Article

O’Neill, Brian, Kevin Lee, Katherine Klaus, Samir Softic, Megan Krumpoch, Joachim Fentz, Kristin Stanford, et al. 2016. “Insulin and IGF-1 Receptors Regulate FoxO-Mediated Signaling in Muscle Proteostasis”. J Clin Invest 126 (9): 3433-46.

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

Publication: Journal Article

Kleinridders, Andre, Weikang Cai, Laura Cappellucci, Armen Ghazarian, William Collins, Sara Vienberg, Emmanuel Pothos, and Ronald Kahn. 2015. “Insulin Resistance in Brain Alters Dopamine Turnover and Causes Behavioral Disorders”. Proc Natl Acad Sci U S A 112 (11): 3463-8.

Insulin signaling and environment

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Microbiome as an environmental modifier of insulin resistance Mitochondrial metabolism, sirtuins, metabolism, aging and stress resistance Fructose and high fat diet as modifiers of metabolic syndrome Modeling insulin resistance and diabetes with human iPS cells Role of miRNAs in insulin action and...