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Role of the transmembrane domain and flanking amino acids in internalization and down-regulation of the insulin receptor

Publication: Journal Article

Yamada, Carpentier, Cheatham, Goncalves, Shoelson, and Kahn. 1995. “Role of the Transmembrane Domain and Flanking Amino Acids in Internalization and Down-Regulation of the Insulin Receptor”. J Biol Chem 270 (7): 3115-22.

Picking a research problem. The critical decision

Publication: Journal Article

Kahn. 1994. “Picking a Research Problem. The Critical Decision”. N Engl J Med 330 (21): 1530-3.

The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases

Publication: Journal Article

Wilden, and Kahn. 1994. “The Level of Insulin Receptor Tyrosine Kinase Activity Modulates the Activities of Phosphatidylinositol 3-Kinase, Microtubule-Associated Protein, and S6 Kinases”. Mol Endocrinol 8 (5): 558-67.

Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone

Publication: Journal Article

Saad, Folli, Araki, Hashimoto, Csermely, and Kahn. 1994. “Regulation of Insulin Receptor, Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase in 3T3-F442A Adipocytes. Effects of Differentiation, Insulin, and Dexamethasone”. Mol Endocrinol 8 (5): 545-57.

The insulin signaling system

Publication: Journal Article

White, and Kahn. 1994. “The Insulin Signaling System”. J Biol Chem 269 (1): 1-4.

Human corneal epithelial primary cultures and cell lines with extended life span: in vitro model for ocular studies

Publication: Journal Article

Kahn, Young, Lee, and Rhim. 1993. “Human Corneal Epithelial Primary Cultures and Cell Lines With Extended Life Span: In Vitro Model for Ocular Studies”. Invest Ophthalmol Vis Sci 34 (12): 3429-41.

Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats

Publication: Journal Article

Saad, Folli, Kahn, and Kahn. 1993. “Modulation of Insulin Receptor, Insulin Receptor Substrate-1, and Phosphatidylinositol 3-Kinase in Liver and Muscle of Dexamethasone-Treated Rats”. J Clin Invest 92 (4): 2065-72.

Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1

Publication: Journal Article

Cheatham, Shoelson, Yamada, Goncalves, and Kahn. 1993. “Substitution of the ErbB-2 Oncoprotein Transmembrane Domain Activates the Insulin Receptor and Modulates the Action of Insulin and Insulin-Receptor Substrate 1”. Proc Natl Acad Sci U S A 90 (15): 7336-40.

Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization

Publication: Journal Article

Araki, Sun, Haag, Chuang, Y. Zhang, Yang-Feng, White, and Kahn. 1993. “Human Skeletal Muscle Insulin Receptor Substrate-1. Characterization of the CDNA, Gene, and Chromosomal Localization”. Diabetes 42 (7): 1041-54.

Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility

Publication: Journal Article

Goncalves, Yamada, Thatte, Backer, Golan, Kahn, and Shoelson. 1993. “Optimizing Transmembrane Domain Helicity Accelerates Insulin Receptor Internalization and Lateral Mobility”. Proc Natl Acad Sci U S A 90 (12): 5762-6.