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Microbiome as an environmental modifier of insulin resistance Mitochondrial metabolism, sirtuins, metabolism, aging and stress resistance Fructose and high fat diet as modifiers of metabolic syndrome Modeling insulin resistance and diabetes with human iPS cells Role of miRNAs in insulin action and...

Our plasmids are available through Addgene.

Over my 30+ year scientific career, a major focus of the laboratory has been mentoring of students and fellows in the laboratory. At present, there are usually between 12-14 post-doctoral fellows, 1-2 students, and 1 visiting scientist in the laboratory. In total, about 150 fellows have trained in...

The Kahn Lab is investigating the mechanism of insulin action and its alterations in insulin resistant states, including type 2 diabetes, obesity and metabolic syndrome. There are 3 major areas of research: 1) Insulin action and insulin resistance. In this area we have projects focusing on the...

Differential signaling by insulin and IGF-1 receptors Differences in downstream signaling (IRS proteins/PI 3-kinase) Signaling by unoccupied insulin receptor Cellular and whole animal analysis using KO and KI mice Signaling in unusual tissues, e.g. the gut and brain