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Lower urinary tract symptoms (LUTS) including overactive bladder, incontinence and flaccid bladder may be the most common complication for patients with diabetes, affecting up to 80–90% of patients by some estimates. We wanted to know which of the mouse strains with high blood glucose would develop...

Team And Collaborators: Mark Zeidel, MD, Principal Investigator Bryce MacIver, PhD, Project Coordinator Aaron Grant, PhD, Director, Preclinical MRI Core at BIDMC Dave Alsop, PhD, Director, Division of Magnetic Resonance Research at BIDMC Cody Callahan, BS, Department of Radiology at BIDMC John Mac...

These studies were funded by an NIH P20 grant [DK108276], to form a Resource Development Project within the BIDMC Department of Medicine’s Center for Interdisciplinary Research in Benign Urology. This Project brings together Department of Radiology Magnetic Resonance Imaging (MRI) physicists and...

Functional MRI Processing for Mouse Micturition Studies Functional MRI (fMRI) studies in rodents is somewhat uncommon as it requires some cognitive or physiological stimulus that causes measurable changes in brain activity. This project however, lends itself well to fMRI studies as voiding induced...

Name Date Current Position Ali Wu, MD Erandi Velaquez-Miranda, PhD Lian Yu Guo, PhD Reina Kobayashi, DVM

Results - Obtained Under Urethane Anesthesia Regions that show activation during CMG peak include the Pontine Micturition Center (PMC), the Periaqueductal Gray (PAG) and the Hypothalamus. The PMC is a small center in the hindbrain that we now know activates bladder contractions, whereas the PAG...