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An orexin agonist promotes wakefulness and inhibits cataplexy through distinct brain regions

Publication: Journal

Ishikawa, Takashi, Emi Kurimoto, Adam A. Joyal, Tatsuki Koike, Haruhide Kimura, and Thomas E. Scammell. 2025. “An Orexin Agonist Promotes Wakefulness and Inhibits Cataplexy through Distinct Brain Regions”. https://doi.org/10.1016/j.cub.2025.03.040.

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Dr. Carrie E Mahoney

Person: Instructor, Department of Neurology, Harvard Medical School, Staff Scientist 1, BIDMC

Dr. Mahoney has examined the role of orexin in promoting arousal and attention in the presence of rewarding stimuli. With mouse models of narcolepsy, she identified neurons of the central nucleus of the amygdala that underlie the triggering of cataplexy (sudden episodes of muscle paralysis) by...

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Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1

Publication: Journal

“Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1”. 2023. https://doi.org/10.1056/NEJMoa2301940.

Catching Up on REMs

Publication: Journal

Burgess, Christian R., and Thomas E. Scammell. 2022. “Catching Up on REMs”. https://doi.org/10.1056/NEJMcibr2203101.

Clinical considerations for the diagnosis of idiopathic hypersomnia

Publication: Journal

Dauvilliers, Yves, Richard K. Bogan, Isabelle Arnulf, Thomas E. Scammell, Erik K. St Louis, and Michael J. Thorpy. 2022. “Clinical Considerations for the Diagnosis of Idiopathic Hypersomnia”. https://doi.org/10.1016/j.smrv.2022.101709 Free article.

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

Publication: Journal

Xiao, Xing, Gagik Yeghiazaryan, Simon Hess, Paul Klemm, Anna Sieben, Andre Kleinridders, Donald A. Morgan, et al. 2021. “Orexin Receptors 1 and 2 in Serotonergic Neurons Differentially Regulate Peripheral Glucose Metabolism in Obesity”. https://doi.org/10.1038/s41467-021-25380-2.

Dr. Jinhwan Choi

Person: BIDMC Postdoctoral Research Fellow BIDMC HMS, PhD

Jinhwan Choi is a postdoctoral researcher in the Department of Neurology at Beth Israel Deaconess Medical Center (BIDMC), affiliated with Harvard Medical School. His research background covers sleep physiology and genetics. His current work aims to understand the neural circuitry of sleep and...