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R01; National Institute of Neurological Disorders and Stroke Targeting the FBXW7/PGC1 Pathway as a Therapeutic Strategy for Parkinson's Disease Principal Investigator(s): David K Simon, Wenyi Wei PGC-1alpha regulates mitochondrial synthesis, and a deficiency PGC-1alpha may play a role in Parkinson’s...

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

Publication: Journal Article

St-Pierre, Julie, Stavit Drori, Marc Uldry, Jessica M Silvaggi, James Rhee, Sibylle Jäger, Christoph Handschin, et al. 2006. “Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators”. Cell.

Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice

Publication: Journal Article

Clark, Joanne, Elizabeth L Clore, Kangni Zheng, Anthony Adame, Eliezer Masliah, and David K Simon. 2010. “Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice”. PLOS ONE.

Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice

Publication: Government Report

Dai, Ying, Kangni Zheng, Joanne Clark, Russell H Swerdlow, Stefan M Pulst, James P Sutton, Leslie A Shinobu, and David K Simon. 2014. “Somatic Mitochondrial DNA Mutations Do Not Increase Neuronal Vulnerability to MPTP in Young POLG Mutator Mice.”

Postdoctoral fellow Dr. Michele Persico presents his work on 2a in vitro at the American Academy of Neurology Annual Meeting

News: April 16, 2024

PGC1-α

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Cloud Carrera Lozano

Person: Prospective Graduate Student

Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model

Publication: Journal Article

Fang, Tracy-Shi Zhang, You Sun, Andrew C Pierce, Simona Eleuteri, Mark Kemp, Christopher A Luckhurst, Rachel Williams, et al. 2023. “Knockout or Inhibition of USP30 Protects Dopaminergic Neurons in a Parkinson’s Disease Mouse Model”. Nature Communication.

2024 BIDMC Annual Research Retreat

News: September 05, 2024

Simon Lab members attended the research retreat. Alejandra and Emily presented "Pharmacological stabilization of the retromer complex results in the reduction of α-synuclein accumulation and in the control of α-synuclein clearance pathways" and joined in conversations about the latest research at...

PGC-1α

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