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Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential
XS, Ding, Gao L, Han Z, Shi W, Shen Y, Song ZY, Su M, et al. 2023. “Ferroptosis in Parkinson’s Disease: Molecular Mechanisms and Therapeutic Potential”. Ageing Research Reviews.
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Sphingolipid and Phospholipid Levels Are Altered in Human Brain in Chorea-Acanthocytosis
Ditzel, RM, RH Walker, MJ Nirenberg, AM Tetlow, K Farrell, KJ Lind-Watson, EL Thorn, et al. 2023. “Sphingolipid and Phospholipid Levels Are Altered in Human Brain in Chorea-Acanthocytosis”. Movement Disorders.
PGC-1α regulation by FBXW7 through a novel mechanism linking chaperone-mediated autophagy and the ubiquitin-proteasome system
Eleuteri, Simona, Bao Wang, Gianni Cutillo, Tracy Shi Zhang Fang, Kai Tao, Yan Qu, Qian Yang, Wenyi Wei, and David K Simon. 2024. “PGC-1α Regulation by FBXW7 through a Novel Mechanism Linking Chaperone-Mediated Autophagy and the Ubiquitin-Proteasome System”. The FEBS Journal.
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USP30
PGC-1α
Funding
R01; National Institute of Neurological Disorders and Stroke Targeting the FBXW7/PGC1 Pathway as a Therapeutic Strategy for Parkinson's Disease Principal Investigator(s): David K Simon, Wenyi Wei PGC-1alpha regulates mitochondrial synthesis, and a deficiency PGC-1alpha may play a role in Parkinson’s...
Pgc-1α overexpression downregulates pitx3 and increases susceptibility to MPTP toxicity associated with decreased bdnf
Clark, J, JM Silvaggi, T Kiselak, K Zheng, E Clore, Y Dai, CE Bass, and DK Simon. 2012. “Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated With Decreased Bdnf”. PLoS ONE.