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A novel experimental model of MetALD in male mice recapitulates key features of severe alcohol-associated hepatitis.

Publication: Journal Article

Babuta, Mrigya, Caroline Morel, Marcelle de Carvalho Ribeiro, Aditi Ashish Datta, Charles Calenda, Christopher Copeland, Imad Nasser, and Gyongyi Szabo. 2024. “A Novel Experimental Model of MetALD in Male Mice Recapitulates Key Features of Severe Alcohol-Associated Hepatitis.”. Hepatology Communications 8 (7).

Efficacy and Safety of Erenumab for Nonopioid Medication Overuse Headache in Chronic Migraine: A Phase 4, Randomized, Placebo-Controlled Trial.

Publication: Journal Article

Tepper, Stewart J, David W Dodick, Michel Lanteri-Minet, David Dolezil, Raquel Gil-Gouveia, Christian Lucas, Karolina Piasecka-Stryczynska, et al. 2024. “Efficacy and Safety of Erenumab for Nonopioid Medication Overuse Headache in Chronic Migraine: A Phase 4, Randomized, Placebo-Controlled Trial.”. JAMA Neurology.

Innate Immune Signaling Pathways

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The pathomechanism of alcoholic liver disease (ALD) involves cumulative events such as leaky gut, hepatocyte damage and inflammation that collectively contribute to the severity of disease. Our studies have delineated the role of Toll-like receptor 4 (TLR4) signaling and identified a unique role for...

Extracellular Vesicles

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Extracellular Vesicles in Alcoholic Liver Disease: Basic and Pre-clinical Discovery A salient feature of alcoholic liver disease is Kupffer cell activation and recruitment of inflammatory monocytes and macrophages. These key cellular events of ALD pathogenesis may be mediated by extracellular...

Intern Students

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Alumni

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Bruna Santos

Person: Graduate Student (Visting)

Derek Desrosier

Person: Intern Student

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Deepika Deepika

Person:

Education: Bachelors, Masters and PhD degree in Biomedical Science Research Projects: I am studying the role of MDSCs in alcohol associated liver disease and their impact on liver fibrosis. Targeting MDSCs in alcohol associated liver disease holds promise for regulating inflammation, fibrosis, and...