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131 results found

Protective effect of LNA-anti-miR-132 therapy on liver fibrosis in mice.

Publication: Journal Article

Momen-Heravi, Fatemeh, Donna Catalano, Austin Talis, Gyongyi Szabo, and Shashi Bala. 2021. “Protective Effect of LNA-Anti-MiR-132 Therapy on Liver Fibrosis in Mice.”. Molecular Therapy. Nucleic Acids 25: 155-67.

Alcohol Promotes Exosome Biogenesis and Release via Modulating Rabs and miR-192 Expression in Human Hepatocytes.

Publication: Journal Article

Bala, Shashi, Mrigya Babuta, Donna Catalano, Aman Saiju, and Gyongyi Szabo. 2021. “Alcohol Promotes Exosome Biogenesis and Release via Modulating Rabs and MiR-192 Expression in Human Hepatocytes.”. Frontiers in Cell and Developmental Biology 9: 787356.

Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice.

Publication: Journal Article

Helsley, Robert N, Tatsunori Miyata, Anagha Kadam, Venkateshwari Varadharajan, Naseer Sangwan, Emily C Huang, Rakhee Banerjee, et al. 2022. “Gut Microbial Trimethylamine Is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice.”. ELife 11.

Research methodologies to address clinical unmet needs and challenges in alcohol-associated liver disease.

Publication: Journal Article

Singal, Ashwani K, Paul Kwo, Allison Kwong, Suthat Liangpunsakul, Alexandre Louvet, Pranoti Mandrekar, Craig McClain, et al. 2022. “Research Methodologies to Address Clinical Unmet Needs and Challenges in Alcohol-Associated Liver Disease.”. Hepatology (Baltimore, Md.) 75 (4): 1026-37.

Neutrophil extracellular traps contribute to liver damage and increase defective low-density neutrophils in alcohol-associated hepatitis.

Publication: Journal Article

Cho, Yeonhee, Terence Ndonyi Bukong, David Tornai, Mrigya Babuta, Ioannis S Vlachos, Eleni Kanata, Donna Catalano, and Gyongyi Szabo. 2023. “Neutrophil Extracellular Traps Contribute to Liver Damage and Increase Defective Low-Density Neutrophils in Alcohol-Associated Hepatitis.”. Journal of Hepatology 78 (1): 28-44.

Design of a multicenter randomized clinical trial for treatment of Alcohol-Associated Hepatitis.

Publication: Journal Article

Tu, Wanzhu, Samer Gawrieh, Srinivasan Dasarathy, Mack C Mitchell, Douglas A Simonetto, Kavish R Patidar, Craig J McClain, et al. 2023. “Design of a Multicenter Randomized Clinical Trial for Treatment of Alcohol-Associated Hepatitis.”. Contemporary Clinical Trials Communications 32: 101074.

Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression.

Publication: Journal Article

Osna, Natalia A, Irina Tikhanovich, Martí Ortega-Ribera, Sebastian Mueller, Chaowen Zheng, Johannes Mueller, Siyuan Li, et al. 2024. “Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression.”. Biomolecules 14 (4).

Contact US

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Gyongyi Szabo, MD, PhD, FAASLD, AGAF, FACP Mitchell T. Rabkin, M.D. Chair Professor of Medicine and Faculty Dean for Academic Affairs Harvard Medical School Chief Academic Officer Beth Israel Lahey Health and Beth Israel Deaconess Medical Center Email: gszabo1@bidmc.harvard.edu Shauntae M. Wilson...

Research

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In our laboratory, we study mechanisms of innate immune activation in liver diseases and its role on modulation of liver parenchymal cells including hepatocytes and stellate cells. We employ a broad range of preclinical murine liver injury models of alcoholic hepatitis, non-alcoholic steatohepatitis...

Biomarkers

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Biomarkers in Liver Disease We are exploring novel therapies and biomarker discoveries in AH. Direct effects of alcohol on hepatocytes, increased intestinal permeability and activation of innate immune system (Kupffer cells) by gut-derived LPS are major factors in AH leading to over-activation of...