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The pathomechanism of alcoholic liver disease (ALD) involves cumulative events such as leaky gut, hepatocyte damage and inflammation that collectively contribute to the severity of disease. Our studies have delineated the role of Toll-like receptor 4 (TLR4) signaling and identified a unique role for...

Extracellular Vesicles in Alcoholic Liver Disease: Basic and Pre-clinical Discovery A salient feature of alcoholic liver disease is Kupffer cell activation and recruitment of inflammatory monocytes and macrophages. These key cellular events of ALD pathogenesis may be mediated by extracellular...