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IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.

Publication: Journal Article

Joshi, Radhika, Veronika Brezani, Gabrielle M Mey, Sergi Guixé-Muntet, Martí Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, and Gyongyi Szabo. 2024. “IRF3 Regulates Neuroinflammatory Responses and the Expression of Genes Associated With Alzheimer’s Disease.”. Journal of Neuroinflammation 21 (1): 212.

miR-21: A therapeutic target for delaying severe liver disease and hepatocellular carcinoma in high-fat-diet-fed mice.

Publication: Journal Article

Jagtap, Urmila, Anan Quan, Yuho Ono, Jonathan Lee, Kylie A Shen, Sergei Manakov, Gyongyi Szabo, Imad Nasser, and Frank J Slack. 2024. “MiR-21: A Therapeutic Target for Delaying Severe Liver Disease and Hepatocellular Carcinoma in High-Fat-Diet-Fed Mice.”. BioRxiv : The Preprint Server for Biology.

A Novel Multi-organ Male Model of Alcohol-induced Acute-on-chronic Liver Failure Reveals NET-mediated Hepatocellular Death, Which is Prevented by RIPK3 Inhibition.

Publication: Journal Article

Ortega-Ribera, Martí, Yuan Zhuang, Mrigya Babuta, Veronika Brezani, Radhika S Joshi, Zsuzsanna Zsengeller, Prashanth Thevkar Nagesh, Yanbo Wang, Roderick Bronson, and Gyongyi Szabo. 2025. “A Novel Multi-Organ Male Model of Alcohol-Induced Acute-on-Chronic Liver Failure Reveals NET-Mediated Hepatocellular Death, Which Is Prevented by RIPK3 Inhibition.”. Cellular and Molecular Gastroenterology and Hepatology 19 (4): 101446.

Parental liver disease mortality is associated with unfavorable outcomes in patients with alcohol-associated hepatitis.

Publication: Journal Article

Tu, Wanzhu, Samer Gawrieh, Lauren Nephew, Craig McClain, Qing Tang, Srinivasan Dasarathy, Vatsalya Vatsalya, et al. 2025. “Parental Liver Disease Mortality Is Associated With Unfavorable Outcomes in Patients With Alcohol-Associated Hepatitis.”. Hepatology Communications 9 (6).

Welcome to New and Returning Student Interns at Szabo Lab!

News: June 01, 2024

Research

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Alchohol and Monocyte Signaling

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Macrophages (MØ), Kupffer cells (KC), and neutrophils mediate inflammation and play an important role in the pathogenesis of alcoholic liver disease (ALD). Previous studies have demonstrated the damaging effects of pro-inflammatory macrophages on alcoholic liver inflammation and high neutrophil...

microRNAs

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microRNA’s in Alcoholic Liver Disease Alcoholic liver disease affects millions of people worldwide and it remains to be a therapeutic challenge for clinicians. Activation of the inflammatory cascade via gut-derived lipopolysaccharide (LPS) contributes to alcoholic liver disease via induction of pro...

Clinical Alcoholic Hepatitis

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Alcoholic Hepatitis Clinical and Translational Network Late Phase Clinical Trials and Observational Studies Alcoholic liver disease (ALD) is a major cause of liver-related morbidity and mortality in the US. Alcoholic hepatitis (AH) is a life-threatening form of ALD. Severe AH is associated with a...