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Safety, Pharmacokinetics, and Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-Associated Hepatitis.

Publication: Journal Article

Hassanein, Tarek, Craig J McClain, Vatsalya Vatsalya, Lance L Stein, Steven L Flamm, Paul Martin, Matthew C Cave, et al. 2024. “Safety, Pharmacokinetics, and Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-Associated Hepatitis.”. The American Journal of Gastroenterology 119 (1): 107-15.

Reply: Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation.

Publication: Journal Article

Ribeiro, Marcelle de Carvalho, Mrigya Babuta, and Gyongyi Szabo. 2024. “Reply: Alcohol-Induced Extracellular ASC Specks Perpetuate Liver Inflammation and Damage in Alcohol-Associated Hepatitis Even After Alcohol Cessation.”. Hepatology (Baltimore, Md.) 79 (2): E28-E29.

IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.

Publication: Journal Article

Joshi, Radhika, Veronika Brezani, Gabrielle M Mey, Sergi Guixé-Muntet, Martí Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, and Gyongyi Szabo. 2024. “IRF3 Regulates Neuroinflammatory Responses and the Expression of Genes Associated With Alzheimer’s Disease.”. BioRxiv : The Preprint Server for Biology.

Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis.

Publication: Journal Article

Gawrieh, Samer, Srinivasan Dasarathy, Wanzhu Tu, Patrick S Kamath, Naga P Chalasani, Craig J McClain, Ramon Bataller, et al. 2024. “Randomized Trial of Anakinra Plus Zinc Vs. Prednisone for Severe Alcohol-Associated Hepatitis.”. Journal of Hepatology 80 (5): 684-93.

Combined Insults of a MASH Diet and Alcohol Binges Activate Intercellular Communication and Neutrophil Recruitment via the NLRP3-IL-1β Axis in the Liver.

Publication: Journal Article

Babuta, Mrigya, Prashanth Thevkar Nagesh, Aditi Ashish Datta, Victoria Remotti, Yuan Zhuang, Jeeval Mehta, Francesca Lami, Yanbo Wang, and Gyongyi Szabo. 2024. “Combined Insults of a MASH Diet and Alcohol Binges Activate Intercellular Communication and Neutrophil Recruitment via the NLRP3-IL-1β Axis in the Liver.”. Cells 13 (11).

Reply: How does bile acid-induced IRF3 phosphorylation mediate cholestatic liver and kidney injury?-More needs to be known.

Publication: Journal Article

Zhuang, Yuan, and Gyongyi Szabo. 2024. “Reply: How Does Bile Acid-Induced IRF3 Phosphorylation Mediate Cholestatic Liver and Kidney Injury?-More Needs to Be Known.”. Hepatology (Baltimore, Md.) 80 (1): E2-E3.

Acute kidney injury in severe alcohol-associated hepatitis treated with anakinra plus zinc or prednisone.

Publication: Journal Article

Patidar, Kavish R, Wanzhu Tu, Thomas G Cotter, Douglas A Simonetto, Amon Asgharpour, Muhammad Y Jan, Qing Tang, et al. 2024. “Acute Kidney Injury in Severe Alcohol-Associated Hepatitis Treated With Anakinra Plus Zinc or Prednisone.”. Hepatology (Baltimore, Md.).

In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis.

Publication: Journal Article

Nagesh, Prashanth Thevkar, Yeonhee Cho, Yuan Zhuang, Mrigya Babuta, Martí Ortega-Ribera, Radhika Joshi, Veronika Brezani, et al. 2024. “In Vivo Bruton’s Tyrosine Kinase Inhibition Attenuates Alcohol-Associated Liver Disease by Regulating CD84-Mediated Granulopoiesis.”. Science Translational Medicine 16 (759): eadg1915.

Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer's disease associated with inflammasome activation and ASC speck propagation.

Publication: Journal Article

Brezani, Veronika, Radhika S Joshi, Martí Ortega-Ribera, Prashanth Thevkar Nagesh, Viliam Brezani, Adam Zivny, Evelyn A Kurt-Jones, Douglas T Golenbock, and Gyongyi Szabo. 2025. “Ethanol Consumption Aggravates Amyloid Pathology and Neuroinflammation in Alzheimer’s Disease Associated With Inflammasome Activation and ASC Speck Propagation.”. Journal of Neuroinflammation 22 (1): 183.

Veronika Brezani, PhD

Person: Postdoctoral Research Fellow

PharmD and Master in Pharmacy, Doctoral degree in Molecular and Cellular Interactions, Doctoral degree in Pharmacognosy I am currently Studying liver-brain communication via exosomes and their miRNA cargo in the context of alcohol use and alcohol-induced liver damage I am also Investigating the...