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The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1.

Qin, Liuliang, Dezheng Zhao, Jianfeng Xu, Xianghui Ren, Ernest F Terwilliger, Sareh Parangi, Jack Lawler, Harold F Dvorak, and Huiyan Zeng. 2013. “The Vascular Permeabilizing Factors Histamine and Serotonin Induce Angiogenesis through TR3/Nur77 and Subsequently Truncate It through Thrombospondin-1.”. Blood 121 (11): 2154-64.

Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression.

Hamano, Yuki, Hikaru Sugimoto, Mary A Soubasakos, Mark Kieran, Bjorn R Olsen, Jack Lawler, Akulapalli Sudhakar, and Raghu Kalluri. 2004. “Thrombospondin-1 Associated With Tumor Microenvironment Contributes to Low-Dose Cyclophosphamide-Mediated Endothelial Cell Apoptosis and Tumor Growth Suppression.”. Cancer Research 64 (5): 1570-4.