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207 results found

Normalizing Tumor Vasculature to Reduce Hypoxia, Enhance Perfusion, and Optimize Therapy Uptake.

Publication: Journal Article

Matuszewska, Kathy, Madison Pereira, Duncan Petrik, Jack Lawler, and Jim Petrik. 2021. “Normalizing Tumor Vasculature to Reduce Hypoxia, Enhance Perfusion, and Optimize Therapy Uptake.”. Cancers 13 (17).

Fluvastatin inhibits intimal hyperplasia in wild-type but not Thbs1-null mice.

Publication: Journal Article

Desai, Pratik, Alex Helkin, Adeola Odugbesi, Jeff Stein, David Bruch, Jack Lawler, Kristopher G Maier, and Vivian Gahtan. 2017. “Fluvastatin Inhibits Intimal Hyperplasia in Wild-Type But Not Thbs1-Null Mice.”. The Journal of Surgical Research 210: 1-7.

Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis.

Publication: Journal Article

Lopez-Dee, Zenaida P, Sridar Chittur V, Hiral Patel, Aleona Chinikaylo, Brittany Lippert, Bhumi Patel, Jack Lawler, and Linda S Gutierrez. 2015. “Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis.”. PloS One 10 (10): e0139918.

ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer.

Publication: Journal Article

Greenaway, James, Jack Henkin, Jack Lawler, Roger Moorehead, and Jim Petrik. 2009. “ABT-510 Induces Tumor Cell Apoptosis and Inhibits Ovarian Tumor Growth in an Orthotopic, Syngeneic Model of Epithelial Ovarian Cancer.”. Molecular Cancer Therapeutics 8 (1): 64-74.

The Tyrosine Kinase Inhibitor Lenvatinib Inhibits Anaplastic Thyroid Carcinoma Growth by Targeting Pericytes in the Tumor Microenvironment.

Publication: Journal Article

Iesato, Asumi, Stephanie Li, Peter M Sadow, Mohammadreza Abbasian, Ara Nazarian, Jack Lawler, and Carmelo Nucera. 2023. “The Tyrosine Kinase Inhibitor Lenvatinib Inhibits Anaplastic Thyroid Carcinoma Growth by Targeting Pericytes in the Tumor Microenvironment.”. Thyroid : Official Journal of the American Thyroid Association 33 (7): 835-48.

Thrombospondin Structure

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Five members of the TSP gene family have been identified (Fig. 1). TSP-1 and -2 (Subgroup A) are similar in their domain structure and the fact that they form disulfide-linked trimers. By contrast, TSP-3 and -4, and cartilage oligomeric matrix protein (COMP) (Subgroup B) assemble into pentamers. An...

Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.

Publication: Journal Article

Lawler, J, M Sunday, V Thibert, M Duquette, E L George, H Rayburn, and R O Hynes. 1998. “Thrombospondin-1 Is Required for Normal Murine Pulmonary Homeostasis and Its Absence Causes Pneumonia.”. The Journal of Clinical Investigation 101 (5): 982-92.

In situ localization of thrombospondin-1 and thrombospondin-3 transcripts in the avian embryo.

Publication: Journal Article

Tucker, R P, C Hagios, R Chiquet-Ehrismann, and J Lawler. 1997. “In Situ Localization of Thrombospondin-1 and Thrombospondin-3 Transcripts in the Avian Embryo.”. Developmental Dynamics : An Official Publication of the American Association of Anatomists 208 (3): 326-37.

Cell-type specific adhesive interactions of skeletal myoblasts with thrombospondin-1.

Publication: Journal Article

Adams, J C, and J Lawler. 1994. “Cell-Type Specific Adhesive Interactions of Skeletal Myoblasts With Thrombospondin-1.”. Molecular Biology of the Cell 5 (4): 423-37.

Colocalization of thrombospondin and syndecan during murine development.

Publication: Journal Article

Corless, C L, A Mendoza, T Collins, and J Lawler. 1992. “Colocalization of Thrombospondin and Syndecan During Murine Development.”. Developmental Dynamics : An Official Publication of the American Association of Anatomists 193 (4): 346-58.