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Data and Protocols

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Nuclei Isolation from human cortical tissue for enrichment of endothelial and microglial cells Click Here GitHub for scripts, data, and protocols

Andrew Gumbert is an MSc candidate at Harvard Medical School in the Biomedical Informatics program. In the Benitez lab, Andrew works as a research student who is interested in applying computational methods to find relationships between omic data and neurodegenerative diseases. Andrew hopes to...

TREM2 is associated with the risk of Alzheimer's disease in Spanish population

Publication: Journal Article

Benitez, BA, B Cooper, P Pastor, SC Jib, E Lorenzo, S Cervantes, and C Cruchaga. 2013. “TREM2 Is Associated With the Risk of Alzheimer’s Disease in Spanish Population”. Neurobiol Aging.

TREM2 and neurodegenerative disease

Publication: Journal Article

Benitez, BA, and C Cruchaga. 2013. “TREM2 and Neurodegenerative Disease”. N Engl J Med.

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

Publication: Journal Article

Deming, Y, F Filipello, F Cignarella, C Cantoni, S Hsu, R Mikesell, X Li, et al. 2019. “The MS4A Gene Cluster Is a Key Modulator of Soluble TREM2 and Alzheimer’s Disease Risk”. Sci Transl Med.

An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology.

Publication: Journal Article

Sheehan, Patrick W, Collin J Nadarajah, Michael F Kanan, Jessica N Patterson, Brenna Novotny, Jennifer H Lawrence, Melvin W King, et al. 2023. “An Astrocyte BMAL1-BAG3 Axis Protects Against Alpha-Synuclein and Tau Pathology.”. Neuron 111 (15): 2383-2398.e7.

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Publication: Journal Article

Bellenguez, Céline, Fahri Küçükali, Iris E Jansen, Luca Kleineidam, Sonia Moreno-Grau, Najaf Amin, Adam C Naj, et al. 2022. “New Insights into the Genetic Etiology of Alzheimer’s Disease and Related Dementias.”. Nature Genetics 54 (4): 412-36.

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion.

Publication: Journal Article

Li, Zeran, Fabiana H G Farias, Umber Dube, Jorge L Del-Aguila, Kathie A Mihindukulasuriya, Maria Victoria Fernandez, Laura Ibanez, et al. 2020. “The TMEM106B FTLD-Protective Variant, Rs1990621, Is Also Associated With Increased Neuronal Proportion.”. Acta Neuropathologica 139 (1): 45-61.

Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?

Publication: Journal Article

Deming, Yuetiva, Zeran Li, Bruno A Benitez, and Carlos Cruchaga. 2018. “Triggering Receptor Expressed on Myeloid Cells 2 (TREM2): A Potential Therapeutic Target for Alzheimer Disease?”. Expert Opinion on Therapeutic Targets 22 (7): 587-98.

Pooled-DNA target sequencing of Parkinson genes reveals novel phenotypic associations in Spanish population.

Publication: Journal Article

Diez-Fairen, Mónica, Bruno A Benitez, Sara Ortega-Cubero, Oswaldo Lorenzo-Betancor, Carlos Cruchaga, Elena Lorenzo, Lluis Samaranch, et al. 2018. “Pooled-DNA Target Sequencing of Parkinson Genes Reveals Novel Phenotypic Associations in Spanish Population.”. Neurobiology of Aging 70: 325.e1-325.e5.