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MicroRNAs in Aging
We found that lin-4 mutants have short lifespans, while lin-4 over-expression extends lifespan and slows aging [1]. This was the first report of a role for miRNAs in regulating lifespan, and led to an intense study in my lab of roles for miRNAs in aging. Initially, we performed high throughput...
Funding
NIH/NIA- JUVENILE MICRORNAS PROMOTING HEALTHIER ADULT AGING: We showed first that microRNAs control aging and that they act upstream of insulin and insulin-like receptor (IIS) and other known longevity pathways. In this proposal, we propose to use discovery-based and hypothesis-based methods that we...
Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo.
Segal, Meirav, Annabelle Biscans, Maud-Emmanuelle Gilles, Eleni Anastasiadou, Roberto De Luca, Jihoon Lim, Anastasia Khvorova, and Frank J Slack. 2020. “Hydrophobically Modified Let-7b MiRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo.”. Molecular Therapy. Nucleic Acids 19: 267-77.
The Role of Non-coding RNAs in Oncology.
Slack, Frank J, and Arul M Chinnaiyan. 2019. “The Role of Non-Coding RNAs in Oncology.”. Cell 179 (5): 1033-55.
Let-7 microRNA as a potential therapeutic target with implications for immunotherapy.
Gilles, Maud-Emmanuelle, and Frank J Slack. 2018. “Let-7 MicroRNA As a Potential Therapeutic Target With Implications for Immunotherapy.”. Expert Opinion on Therapeutic Targets 22 (11): 929-39.
Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas.
Anastasiadou, Eleni, Dina Stroopinsky, Stella Alimperti, Alan L Jiao, Athalia R Pyzer, Claudia Cippitelli, Giuseppina Pepe, et al. 2019. “Epstein-Barr Virus-Encoded EBNA2 Alters Immune Checkpoint PD-L1 Expression by Downregulating MiR-34a in B-Cell Lymphomas.”. Leukemia 33 (1): 132-47.
Personalized RNA Medicine for Pancreatic Cancer.
Gilles, Maud-Emmanuelle, Liangliang Hao, Ling Huang, Rajesha Rupaimoole, Pedro P Lopez-Casas, Emilia Pulver, Jong Cheol Jeong, et al. 2018. “Personalized RNA Medicine for Pancreatic Cancer.”. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 24 (7): 1734-47.
Non-coding RNA networks in cancer.
Anastasiadou, Eleni, Leni S Jacob, and Frank J Slack. 2018. “Non-Coding RNA Networks in Cancer.”. Nature Reviews. Cancer 18 (1): 5-18.
Targeting noncoding RNAs in disease.
Adams, Brian D, Christine Parsons, Lisa Walker, Wen Cai Zhang, and Frank J Slack. 2017. “Targeting Noncoding RNAs in Disease.”. The Journal of Clinical Investigation 127 (3): 761-71.