MicroRNA control of lifespan and metabolism.
Boehm, Michelle, and Frank J Slack. 2006. “MicroRNA Control of Lifespan and Metabolism.”. Cell Cycle (Georgetown, Tex.) 5 (8): 837-40.
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The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans.
Grosshans, Helge, Ted Johnson, Kristy L Reinert, Mark Gerstein, and Frank J Slack. 2005. “The Temporal Patterning MicroRNA Let-7 Regulates Several Transcription Factors at the Larval to Adult Transition in C. Elegans.”. Developmental Cell 8 (3): 321-30.
Architecture of a validated microRNA::target interaction.
Vella, Monica C, Kristy Reinert, and Frank J Slack. 2004. “Architecture of a Validated MicroRNA::Target Interaction.”. Chemistry & Biology 11 (12): 1619-23.
The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR.
Vella, Monica C, Eun-Young Choi, Shin-Yi Lin, Kristy Reinert, and Frank J Slack. 2004. “The C. Elegans MicroRNA Let-7 Binds to Imperfect Let-7 Complementary Sites from the Lin-41 3’UTR.”. Genes & Development 18 (2): 132-7.
The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter.
Johnson, Steven M, Shin Yi Lin, and Frank J Slack. 2003. “The Time of Appearance of the C. Elegans Let-7 MicroRNA Is Transcriptionally Controlled Utilizing a Temporal Regulatory Element in Its Promoter.”. Developmental Biology 259 (2): 364-79.
The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target.
Lin, Shin-Yi, Steven M Johnson, Mary Abraham, Monica C Vella, Amy Pasquinelli, Chiara Gamberi, Ellen Gottlieb, and Frank J Slack. 2003. “The C Elegans Hunchback Homolog, Hbl-1, Controls Temporal Patterning and Is a Probable MicroRNA Target.”. Developmental Cell 4 (5): 639-50.
Host microRNA-31-5p represses oncogenic herpesvirus lytic reactivation by restricting the RNA-binding protein KHDRBS3-mediated viral gene expression.
Lee, Soo Mi, Christopher L Avalos, Christos Miliotis, Hanna M Doh, Erica Chan, Kenneth M Kaye, and Frank J Slack. 2025. “Host MicroRNA-31-5p Represses Oncogenic Herpesvirus Lytic Reactivation by Restricting the RNA-Binding Protein KHDRBS3-Mediated Viral Gene Expression.”. BioRxiv : The Preprint Server for Biology.
tRNA modifications are required for stress granule formation and melanoma metastasis.
Hughes, Riley O, Hannah J Davis, Leona A Nease, Paul Zumbo, Mauro Danielli, Wyatt Tran, Kilian Maidhof, et al. 2025. “TRNA Modifications Are Required for Stress Granule Formation and Melanoma Metastasis.”. BioRxiv : The Preprint Server for Biology.
MicroRNA spatial profiling for assessing drug efficacy in BRCA1 -related triple-negative breast tumors.
Mohd, Omar N, Lin Wang, Brian R Sardella, David Jou, Gerburg M Wulf, Frank J Slack, Yujing J Heng, and Patrick S Doyle. 2026. “MicroRNA Spatial Profiling for Assessing Drug Efficacy in BRCA1 -Related Triple-Negative Breast Tumors.”. BioRxiv : The Preprint Server for Biology.
miR-155 as a novel clinical target for hematological malignancies.
Witten, Lisa, and Frank J Slack. 2020. “MiR-155 As a Novel Clinical Target for Hematological Malignancies.”. Carcinogenesis 41 (1): 2-7.