Search

Search results

227 results found

Drug resistant pancreatic cancer cells exhibit altered biophysical interactions with stromal fibroblasts in imaging studies of 3D co-culture models.

Publication: Journal Article

Struth, Eric, Maryam Labaf, Vida Karimnia, Yiran Liu, Gwendolyn Cramer, Joanna B Dahl, Frank J Slack, Kourosh Zarringhalam, and Jonathan P Celli. 2024. “Drug Resistant Pancreatic Cancer Cells Exhibit Altered Biophysical Interactions With Stromal Fibroblasts in Imaging Studies of 3D Co-Culture Models.”. Scientific Reports 14 (1): 20698.

MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state.

Publication: Journal Article

Zhang, Wen Cai, Nicholas Skiados, Fareesa Aftab, Cerena Moreno, Luis Silva, Paul Joshua Anthony Corbilla, John M Asara, Aaron N Hata, and Frank J Slack. 2022. “MicroRNA-21 Guide and Passenger Strand Regulation of Adenylosuccinate Lyase-Mediated Purine Metabolism Promotes Transition to an EGFR-TKI-Tolerant Persister State.”. Cancer Gene Therapy 29 (12): 1878-94.

Photodynamic Stromal Depletion Enhances Therapeutic Nanoparticle Delivery in 3D Pancreatic Ductal Adenocarcinoma Tumor Models.

Publication: Journal Article

Karimnia, Vida, Elizabeth Stanley, Christian T Fitzgerald, Imran Rizvi, Frank J Slack, and Jonathan P Celli. 2023. “Photodynamic Stromal Depletion Enhances Therapeutic Nanoparticle Delivery in 3D Pancreatic Ductal Adenocarcinoma Tumor Models.”. Photochemistry and Photobiology 99 (1): 120-31.

The Role of LncRNAs in Uveal Melanoma.

Publication: Journal Article

Milán-Rois, Paula, Anan Quan, Frank J Slack, and Álvaro Somoza. 2021. “The Role of LncRNAs in Uveal Melanoma.”. Cancers 13 (16).

The SWI/SNF complex regulates the expression of miR-222, a tumor suppressor microRNA in lung adenocarcinoma.

Publication: Journal Article

Peinado, Paola, Alvaro Andrades, Jordi Martorell-Marugán, Jeffrey R Haswell, Frank J Slack, Pedro Carmona-Sáez, and Pedro P Medina. 2021. “The SWI/SNF Complex Regulates the Expression of MiR-222, a Tumor Suppressor MicroRNA in Lung Adenocarcinoma.”. Human Molecular Genetics 30 (23): 2263-71.

Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia.

Publication: Journal Article

Lee, Jonathan D, Joao A Paulo, Ryan R Posey, Vera Mugoni, Nikki R Kong, Giulia Cheloni, Yu-Ru Lee, et al. 2021. “Dual DNA and Protein Tagging of Open Chromatin Unveils Dynamics of Epigenomic Landscapes in Leukemia.”. Nature Methods 18 (3): 293-302.

sChemNET: a deep learning framework for predicting small molecules targeting microRNA function.

Publication: Journal Article

Galeano, Diego, , Jeffrey Haltom, Chaylen Andolino, Aliza Yousey, Victoria Zaksas, Saswati Das, et al. 2024. “SChemNET: a Deep Learning Framework for Predicting Small Molecules Targeting MicroRNA Function.”. Nature Communications 15 (1): 9149.

Basic & Translational Research

Page

In our laboratory, we study non-coding RNAs, such as miRNAs in basic and translational research. We hope to discover how miRNAs are expressed, what they regulate, how they function, how extensive their reach is, what roles they play in cancer and aging, and then harnessing this new mechanism to...

Lab Members

Page

Advances in peptide nucleic acid for targeting RNA and genomic DNA.

Publication: Journal Article

De, Angana, Vikas Kumar, Mark Saltzman, Frank J Slack, Ajit Vikram, Anisha Gupta, and Raman Bahal. 2026. “Advances in Peptide Nucleic Acid for Targeting RNA and Genomic DNA.”. Cell Reports. Physical Science 7 (1).