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222 results found

MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy.

Publication: Journal Article

Weidhaas, Joanne B, Imran Babar, Sunitha M Nallur, Phong Trang, Sarah Roush, Michelle Boehm, Erin Gillespie, and Frank J Slack. 2007. “MicroRNAs As Potential Agents to Alter Resistance to Cytotoxic Anticancer Therapy.”. Cancer Research 67 (23): 11111-6.

microRNA-mediated silencing inside P-bodies.

Publication: Journal Article

Chan, Shih-Peng, and Frank J Slack. 2006. “MicroRNA-Mediated Silencing Inside P-Bodies.”. RNA Biology 3 (3): 97-100.

Basic & Translational Research

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In our laboratory, we study non-coding RNAs, such as miRNAs in basic and translational research. We hope to discover how miRNAs are expressed, what they regulate, how they function, how extensive their reach is, what roles they play in cancer and aging, and then harnessing this new mechanism to...

MicroRNAs in Developmental Timing

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Our interest in miRNAs began with a desire to solve the fundamental question of how organs form at the right time during development [1, 4], and this core theme has since led us to a broader interest in the role of miRNAs in human disease and aging [5, 6]. We initially focused on using C. elegans to...

Lab Members

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Graduate Students

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Name Dates Current Position Paola Peinado (Visiting Student) 2018 PhD candidate in Biochemistry and Molecular Biology, University of Granada, Spain Julia Ramirez Moya (Visiting Student) 2018 PhD candidate in Molecular Biomedicine, Autonomous University of Madrid, Spain Lisa Witten 2015-2019...

Epstein-Barr virus: From kisses to cancer, an ingenious immune evader.

Publication: Journal Article

Trivedi, Pankaj, Frank J Slack, and Eleni Anastasiadou. 2018. “Epstein-Barr Virus: From Kisses to Cancer, an Ingenious Immune Evader.”. Oncotarget 9 (92): 36411-12.

lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

Publication: Journal Article

Jiao, Alan L, Daniel J Foster, Julia Dixon, and Frank J Slack. 2018. “Lin-4 and the NRDE Pathway Are Required to Activate a Transgenic Lin-4 Reporter But Not the Endogenous Lin-4 Locus in C. Elegans.”. PloS One 13 (1): e0190766.

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases.

Publication: Journal Article

Rupaimoole, Rajesha, and Frank J Slack. 2017. “MicroRNA Therapeutics: Towards a New Era for the Management of Cancer and Other Diseases.”. Nature Reviews. Drug Discovery 16 (3): 203-22.

Cis-acting elements in its 3' UTR mediate post-transcriptional regulation of KRAS.

Publication: Journal Article

Kim, Minlee, Nicole Kogan, and Frank J Slack. 2016. “Cis-Acting Elements in Its 3’ UTR Mediate Post-Transcriptional Regulation of KRAS.”. Oncotarget 7 (11): 11770-84.