Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function.
Larocca, Rafael A, Nicholas M Provine, Malika Aid, Justin Iampietro, Erica N Borducchi, Alexander Badamchi-Zadeh, Peter Abbink, et al. 2016. “Adenovirus Serotype 5 Vaccine Vectors Trigger IL-27-Dependent Inhibitory CD4+ T Cell Responses That Impair CD8+ T Cell Function.”. Science Immunology 1 (5).