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Our facilities were updated and re-launched as an institutional Energy Balance Metabolic Core in 2019 to continue the tradition of excellence in metabolic research. This included a bomb calorimeter and a thermal imaging camera. In 2020 we obtained a Promethion indirect calorimeter and DSI’s...

​ Male C57Bl/6J mice housed at thermoneutrality were administered the β-adrenergic agonist CL 316,243, and changes in oxygen consumption were continuously measured.

C57Bl/6J female mice were monitored for body temperature and metabolic rate during the dark photoperiod without food, with the blue trace representing a fed mouse and the red trace a fasted mouse exhibiting torpor (Hrvatin et al., Nature 2020).

In vivo stable isotope tracing with U-¹³C₆ D-mannitol and U-¹³C₆ D-glucose was conducted to enable ¹³CO₂ monitoring in the Promethion indirect calorimeter, with data plotted using CalR for conventional (blue) and commensal-depleted (red) mice (Vieira et al., in press).

Sable Systems Promethion Indirect Calorimeter (32 cages) Food intake Water intake In-cage body mass measurement Physical activity (infrared beam breaks) Energy expenditure Oxygen consumption (VO2) Carbon dioxide production (VCO2) Respiratory exchange ratio – an indicator of carbohydrate or fat...

Male C57Bl/6J mice (10–14 weeks, JAX) were monitored in the Promethion indirect calorimeter at 30°C, 23°C, and 4°C, tracking body weight and energy expenditure, with data analyzed in CalR. ​

C57Bl/6J male mice were monitored in the Promethion indirect calorimeter, and data were analyzed in CalR to compare energy expenditure between T3-treated and vehicle groups (Hochbaum et al., Cell, 2024).

Analysis of diet-induced obesity experiments in male C57Bl/6J mice on a low-fat diet (LFD) or high-fat diet (HFD), demonstrating differences in body weight, energy intake, expenditure, and balance (Banks et al., Nature Metabolism, 2025). ​

Mice expressing DREADDs and non-DREADD controls were monitored in the Promethion indirect calorimeter, with CNO administered at hour 4 and data plotted in CalR.