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Target validation of agents or combinations of agents in cell culture in one or more murine and human tumor cell lines or mouse embryonic fibroblasts (MEFs) of various genotypes (see below). Use of several different assays depending upon the agent and type of information sought. Availability of an...

Agents alone or in combination will be evaluated in vivo in human tumor xenografts in mice, as well as in GEMs obtained by outsourcing or in-house acquisition when requested. We will evaluate each drug or combination of drugs by different routes or different schedules of administration following...

APL as a Novel Paradigm for Experimental Therapeutics Acute promyelocytic leukemia (APL) is associated with the accumulation in the bone marrow of tumor cells with promyelocytic features and the invariable association with specific reciprocal chromosomal translocations involving the retinoic acid...