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Differential requirement of mTOR in postmitotic tissues and tumorigenesis.

Publication: Journal Article

Nardella, Caterina, Arkaitz Carracedo, Andrea Alimonti, Robin M Hobbs, John G Clohessy, Zhenbang Chen, Ainara Egia, et al. 2009. “Differential Requirement of MTOR in Postmitotic Tissues and Tumorigenesis.”. Science Signaling 2 (55): ra2.

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Improving Human Health Through Preclinical Trials in Mouse Models of Human Disease The goal of our facility, which is partially funded by Dana Farber/Harvard Cancer Center, is to provide expertise in the design and implementation of preclinical trials to test new drugs, drug combinations and novel...

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Proper Citation Beth Israel Deaconess Medical Center - Preclinical Murine Pharmacogenetics Facility, RRID: SCR_026599 From an Idea to Its Realization An investigator has an idea for a new preclinical trial and takes it to Core Director for consultation. The Core Director provides advise in the study...

Toker Cell Hyperplasia in the Nipple-Areolar Complex of Transmasculine Individuals.

Publication: Journal Article

Baker, Gabrielle M, Vanessa C Bret-Mounet, Jingxiong Xu, Valerie J Fein-Zachary, Adam M Tobias, Richard A Bartlett, John G Clohessy, et al. 2023. “Toker Cell Hyperplasia in the Nipple-Areolar Complex of Transmasculine Individuals.”. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc 36 (6): 100121.

Maroni, Giorgia, Mahmoud A Bassal, Indira Krishnan, Chee Wai Fhu, Virginia Savova, Rapolas Zilionis, Valerie A Maymi, et al. 2021. “Identification of a Targetable KRAS-Mutant Epithelial Population in Non-Small Cell Lung Cancer.”. Communications Biology 4 (1): 370.

Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia.

Publication: Journal Article

Lee, Jonathan D, Joao A Paulo, Ryan R Posey, Vera Mugoni, Nikki R Kong, Giulia Cheloni, Yu-Ru Lee, et al. 2021. “Dual DNA and Protein Tagging of Open Chromatin Unveils Dynamics of Epigenomic Landscapes in Leukemia.”. Nature Methods 18 (3): 293-302.

PDX-derived organoids model in vivo drug response and secrete biomarkers.

Publication: Journal Article

Huang, Ling, Bruno Bockorny, Indranil Paul, Dipikaa Akshinthala, Pierre-Oliver Frappart, Omar Gandarilla, Arindam Bose, et al. 2020. “PDX-Derived Organoids Model in Vivo Drug Response and Secrete Biomarkers.”. JCI Insight 5 (21).

CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer.

Publication: Journal Article

Ali, Azhar, Elena Levantini, Chee Wai Fhu, Jun Ting Teo, John G Clohessy, Julian L Goggi, Chan-Shuo Wu, Leilei Chen, Tan Min Chin, and Daniel G Tenen. 2019. “CAV1 - GLUT3 Signaling Is Important for Cellular Energy and Can Be Targeted by Atorvastatin in Non-Small Cell Lung Cancer.”. Theranostics 9 (21): 6157-74.

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Differential requirement of mTOR in postmitotic tissues and tumorigenesis.

About Us

Procedures and Policies

Toker Cell Hyperplasia in the Nipple-Areolar Complex of Transmasculine Individuals.

Targeting of microRNA-22 Suppresses Tumor Spread in a Mouse Model of Triple-Negative Breast Cancer.

Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer.

Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia.

PDX-derived organoids model in vivo drug response and secrete biomarkers.

CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer.