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Maximizing statistical power to detect clinically associated cell states with scPOST

Publication: Journal Article

Millard, Korsunsky, Kathryn Weinand, CY Fonseka, Nathan, Kang, and Raychaudhuri. 2021. “Maximizing Statistical Power to Detect Clinically Associated Cell States With ScPOST”. Cell Rep Methods 1 (8): PMCID: PMC8740883.

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

Publication: Journal Article

Ishigaki, Lagattuta, Luo, James, Buckner, and Raychaudhuri. 2020. “HLA Autoimmune Risk Alleles Restrict the Hypervariable Region of T Cell Receptors.”

Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements

Publication: Journal Article

Amariuta, Ishigaki, Sugishita, Ohta, Koido, Dey, Matsuda, et al. 2020. “Improving the Trans-Ancestry Portability of Polygenic Risk Scores by Prioritizing Variants in Predicted Cell-Type-Specific Regulatory Elements”. Nature Genetics 52: 1346-54.

Kaitlyn Lagattuta

Person: Harvard Medical School MD-PhD Student

I'm an MD/PhD student (MD though the Harvard/MIT HST program and PhD in Bioinformatics & Integrative Genomics). I joined the Raychaudhuri lab in the summer of 2020, and I am currently analyzing covariation between T cell receptor (TCR) sequence features and T cell phenotype. More broadly, I am...