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Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits

Publication: Journal Article

Hormozdiari, Farhad, Steven Gazal, Bryce Geijn, Hilary Finucane, Chelsea Ju, Po-Ru Loh, Armin Schoech, et al. 2018. “Leveraging Molecular Quantitative Trait Loci to Understand the Genetic Architecture of Diseases and Complex Traits”. Nat Genet 50 (7): 1041-47.

Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations

Publication: Journal Article

Gazal, Steven, Po-Ru Loh, Hilary Finucane, Andrea Ganna, Armin Schoech, Shamil Sunyaev, and Alkes Price. 2018. “Functional Architecture of Low-Frequency Variants Highlights Strength of Negative Selection across Coding and Non-Coding Annotations”. Nat Genet 50 (11): 1600-1607.

Upcoming presentations on clonal hematopoiesis

News: January 26, 2018

Po-Ru Loh will be presenting work on mosaic CNV detection using long-range phasing at the Broad Institute MIA Seminar on Wed 2/21 (with Giulio Genovese), the MIT Bioinformatics Seminar on Wed 2/21, and the UCLA Computational Genomics Winter Institute on Mon 2/26.

Mixed model association paper published in Nature Genetics

News: June 11, 2018

This paper, " Mixed-model association for biobank-scale datasets" (Loh et al. 2018 Nat Genet), explores best practices for genome-wide association analyses in very large cohorts.

Alison R. Barton

Person: Ph.D. Student, Harvard Medical School Bioinformatics and Integrative Genomics (BIG), -> Postdoctoral Fellow, Harvard Medical School Department of Genetics

Alison joined the lab as a PhD candidate in Bioinformatics and Integrative Genomics at Harvard University. She previously studied Molecular, Cellular, and Developmental Biology and Archaeological Studies at Yale College. After undergrad, she went on to earn an MPhil in genetics at Cambridge...

Alison Barton has joined the lab!

News: December 10, 2018

Alison is a PhD candidate in the Harvard Medical School BIG program and is interested in studying the role of human genetic variation and population history in health and disease. Welcome, Alison!

A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases

Publication: Journal Article

Zhu, Zhaozhong, Phil Lee, Mark Chaffin, Wonil Chung, Po-Ru Loh, Quan Lu, David Christiani, and Liming Liang. 2018. “A Genome-Wide Cross-Trait Analysis from UK Biobank Highlights the Shared Genetic Architecture of Asthma and Allergic Diseases”. Nat Genet 50 (6): 857-64.

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

Publication: Journal Article

Finucane, Hilary, Yakir A Reshef, Verneri Anttila, Kamil Slowikowski, Alexander Gusev, Andrea Byrnes, Steven Gazal, et al. 2018. “Heritability Enrichment of Specifically Expressed Genes Identifies Disease-Relevant Tissues and Cell Types”. Nat Genet 50 (4): 621-29.

Talk on mosaic CNVs at Harvard Biostats / DBMI Big Data Seminar

News: April 30, 2018

Po-Ru Loh will be presenting work on mosaic CNVs in clonal hematopoiesis and brain development at the Harvard Biostatistics / HMS Department of Biomedical Informatics B3D Seminar on Mon 4/30.

Po-Ru Loh receives NIH Director's New Innovator Award

News: October 02, 2018

Po-Ru Loh has been selected for a 2018 NIH Director's New Innovator Award, which supports "unusually innovative research from early career investigators." The proposed project (" Revealing Somatic Genome Alterations and Their Clinical Sequelae: Ultrasensitive Computational Detection of Mosaic...