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Alison R. Barton

Person: Ph.D. Student, Harvard Medical School Bioinformatics and Integrative Genomics (BIG), -> Postdoctoral Fellow, Harvard Medical School Department of Genetics

Alison joined the lab as a PhD candidate in Bioinformatics and Integrative Genomics at Harvard University. She previously studied Molecular, Cellular, and Developmental Biology and Archaeological Studies at Yale College. After undergrad, she went on to earn an MPhil in genetics at Cambridge...

Alison Barton has joined the lab!

News: December 10, 2018

Alison is a PhD candidate in the Harvard Medical School BIG program and is interested in studying the role of human genetic variation and population history in health and disease. Welcome, Alison!

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits

Publication: Journal Article

Hormozdiari, Farhad, Steven Gazal, Bryce Geijn, Hilary Finucane, Chelsea Ju, Po-Ru Loh, Armin Schoech, et al. 2018. “Leveraging Molecular Quantitative Trait Loci to Understand the Genetic Architecture of Diseases and Complex Traits”. Nat Genet 50 (7): 1041-47.

Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations

Publication: Journal Article

Gazal, Steven, Po-Ru Loh, Hilary Finucane, Andrea Ganna, Armin Schoech, Shamil Sunyaev, and Alkes Price. 2018. “Functional Architecture of Low-Frequency Variants Highlights Strength of Negative Selection across Coding and Non-Coding Annotations”. Nat Genet 50 (11): 1600-1607.

Upcoming presentations on clonal hematopoiesis

News: January 26, 2018

Po-Ru Loh will be presenting work on mosaic CNV detection using long-range phasing at the Broad Institute MIA Seminar on Wed 2/21 (with Giulio Genovese), the MIT Bioinformatics Seminar on Wed 2/21, and the UCLA Computational Genomics Winter Institute on Mon 2/26.

Mixed model association paper published in Nature Genetics

News: June 11, 2018

This paper, " Mixed-model association for biobank-scale datasets" (Loh et al. 2018 Nat Genet), explores best practices for genome-wide association analyses in very large cohorts.

Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations

Publication: Journal Article

Loh, Po-Ru, Giulio Genovese, Robert Handsaker, Hilary Finucane, Yakir A Reshef, Pier Francesco Palamara, Brenda Birmann, et al. 2018. “Insights into Clonal Haematopoiesis from 8,342 Mosaic Chromosomal Alterations”. Nature 559 (7714): 350-55.

Maxwell A. Sherman

Person: Ph.D. Student, MIT Electrical Engineering and Computer Science (EECS), -> Co-Founder & CTO, Serinus Biosciences

Max is a PhD student in Electrical Engineering and Computer Science (EECS) at MIT. He previously studied applied mathematics at Brown University and theoretical statistics at the University of Cambridge before working as a scientific programmer in Peter Park's computational genomics group at Harvard...

Max Sherman has joined the lab!

News: August 14, 2018

Max is starting a PhD program at MIT EECS and is interested in how population patterns learned from biobank data can be used to predict traits, diseases and health outcomes for individuals. Welcome, Max!

Highlights

Page

Selected Preprints Mukamel RE*, Handsaker RE*, Sherman MA, Barton AR, Hujoel MLA, McCarroll SA**, Loh PR**. Repeat polymorphisms in non-coding DNA underlie top genetic risk loci for glaucoma and colorectal cancer. medRxiv (2022). [ pdf + supp] Selected Publications Hujoel MLA, Sherman MA, Barton AR...