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Po-Ru Loh receives Sloan Research Fellowship

News: February 19, 2019

Po-Ru Loh has been awarded a 2019 Sloan Research Fellowship in Computational and Evolutionary Molecular Biology.

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

Publication: Journal Article

Schoech, Armin, Daniel Jordan, Po-Ru Loh, Steven Gazal, Luke O’Connor, Daniel Balick, Pier Palamara, Hilary Finucane, Shamil R. Sunyaev, and Alkes Price. 2019. “Quantification of Frequency-Dependent Genetic Architectures in 25 UK Biobank Traits Reveals Action of Negative Selection”. Nat Commun 10 (1): 790.

Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes

Publication: Journal Article

Chung, Wonil, Jun Chen, Constance Turman, Sara Lindström, Zhaozhong Zhu, Po-Ru Loh, Peter Kraft, and Liming Liang. 2019. “Efficient Cross-Trait Penalized Regression Increases Prediction Accuracy in Large Cohorts Using Secondary Phenotypes”. Nat Commun 10 (1): 569.

Estimating cross-population genetic correlations of causal effect sizes

Publication: Journal Article

Galinsky, Kevin, Yakir A Reshef, Hilary Finucane, Po-Ru Loh, Noah Zaitlen, Nick Patterson, Brielin Brown, and Alkes Price. 2019. “Estimating Cross-Population Genetic Correlations of Causal Effect Sizes”. Genet Epidemiol 43 (2): 180-88.

Fast, sensitive and accurate integration of single-cell data with Harmony

Publication: Journal Article

Korsunsky, Ilya, Nghia Millard, Jean Fan, Kamil Slowikowski, Fan Zhang, Kevin Wei, Yuriy Baglaenko, Michael Brenner, Po-Ru Loh, and Soumya Raychaudhuri. 2019. “Fast, Sensitive and Accurate Integration of Single-Cell Data With Harmony”. Nat Methods 16 (12): 1289-96.

Ronen Mukamel has joined the lab!

News: January 14, 2019

Ronen is an Instructor at Harvard Medical School and is interested in structural variation in human genomes and its effects on human health. Welcome, Ronen!

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

Publication: Journal Article

Geijn, Bryce, Hilary Finucane, Steven Gazal, Farhad Hormozdiari, Tiffany Amariuta, Xuanyao Liu, Alexander Gusev, et al. 2019. “Annotations Capturing Cell-Type-Specific TF Binding Explain a Large Fraction of Disease Heritability”. Hum Mol Genet.

Talks and posters from our group at ASHG 2019

News: October 16, 2019

At ASHG this year, Max Sherman will be speaking about his work on mosaic CNVs in autism (Thu 10/17 at 9:45am, #105) and Po-Ru Loh will be speaking about his work on clonal hematopoiesis in UK Biobank (Sat 10/19 at 10:45am, #343). Ronen Mukamel and Alison Barton will be presenting posters exploring...

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Publication: Journal Article

Warrington, Nicole, Robin Beaumont, Momoko Horikoshi, Felix Day, Øyvind Helgeland, Charles Laurin, Jonas Bacelis, et al. 2019. “Maternal and Fetal Genetic Effects on Birth Weight and Their Relevance to Cardio-Metabolic Risk Factors”. Nat Genet 51 (5): 804-14.

Ronen E. Mukamel

Person: Instructor, Harvard Medical School

My current research focus is on structural variation in human genomes and the impact of structural variants on human health. My background is in pure mathematics, specifically the geometry of surfaces and billiards in polygons. When I am not engaged in research, I prefer to be walking up a mountain...