Po-Ru Loh receives Sloan Research Fellowship
Po-Ru Loh has been awarded a 2019 Sloan Research Fellowship in Computational and Evolutionary Molecular Biology.
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17 results found
Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
Schoech, Armin, Daniel Jordan, Po-Ru Loh, Steven Gazal, Luke O’Connor, Daniel Balick, Pier Palamara, Hilary Finucane, Shamil R. Sunyaev, and Alkes Price. 2019. “Quantification of Frequency-Dependent Genetic Architectures in 25 UK Biobank Traits Reveals Action of Negative Selection”. Nat Commun 10 (1): 790.
Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes
Chung, Wonil, Jun Chen, Constance Turman, Sara Lindström, Zhaozhong Zhu, Po-Ru Loh, Peter Kraft, and Liming Liang. 2019. “Efficient Cross-Trait Penalized Regression Increases Prediction Accuracy in Large Cohorts Using Secondary Phenotypes”. Nat Commun 10 (1): 569.
Estimating cross-population genetic correlations of causal effect sizes
Galinsky, Kevin, Yakir A Reshef, Hilary Finucane, Po-Ru Loh, Noah Zaitlen, Nick Patterson, Brielin Brown, and Alkes Price. 2019. “Estimating Cross-Population Genetic Correlations of Causal Effect Sizes”. Genet Epidemiol 43 (2): 180-88.
Fast, sensitive and accurate integration of single-cell data with Harmony
Korsunsky, Ilya, Nghia Millard, Jean Fan, Kamil Slowikowski, Fan Zhang, Kevin Wei, Yuriy Baglaenko, Michael Brenner, Po-Ru Loh, and Soumya Raychaudhuri. 2019. “Fast, Sensitive and Accurate Integration of Single-Cell Data With Harmony”. Nat Methods 16 (12): 1289-96.
Ronen Mukamel has joined the lab!
Ronen is an Instructor at Harvard Medical School and is interested in structural variation in human genomes and its effects on human health. Welcome, Ronen!
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Terao, Chikashi, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, et al. 2019. “GWAS of Mosaic Loss of Chromosome Y Highlights Genetic Effects on Blood Cell Differentiation”. Nat Commun 10 (1): 4719.
Genetic predisposition to mosaic Y chromosome loss in blood
Thompson, Deborah, Giulio Genovese, Jonatan Halvardson, Jacob Ulirsch, Daniel Wright, Chikashi Terao, Olafur Davidsson, et al. 2019. “Genetic Predisposition to Mosaic Y Chromosome Loss in Blood”. Nature 575 (7784): 652-57.
Genes with High Network Connectivity Are Enriched for Disease Heritability
Kim, Samuel, Chengzhen Dai, Farhad Hormozdiari, Bryce Geijn, Steven Gazal, Yongjin Park, Luke O’Connor, et al. 2019. “Genes With High Network Connectivity Are Enriched for Disease Heritability”. Am J Hum Genet 104 (5): 896-913.
Leveraging Polygenic Functional Enrichment to Improve GWAS Power
Kichaev, Gleb, Gaurav Bhatia, Po-Ru Loh, Steven Gazal, Kathryn Burch, Malika Freund, Armin Schoech, Bogdan Pasaniuc, and Alkes Price. 2019. “Leveraging Polygenic Functional Enrichment to Improve GWAS Power”. Am J Hum Genet 104 (1): 65-75.