Contact
Kahn Laboratory Lab PI: C. Ronald Kahn ( C.Ronald.Kahn@joslin.harvard.edu) 6th floor Joslin Diabetes Center 1 Joslin Place 02215 Boston
Search
Search results
33 results found
Contact
Adipogenesis - Interorgan communication
Brown vs. beige vs. white adipose tissue Heterogeneity of white adipose tissue (even within a single depot) Role of developmental genes and miRNAs in adipose function Adipose tissue circulating miRNAs and interorgan communication
Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes
Boucher, Jeremie, Marika Charalambous, Kim Zarse, Marcelo Mori, Andre Kleinridders, Michael Ristow, Anne Ferguson-Smith, and Ronald Kahn. 2014. “Insulin and Insulin-Like Growth Factor 1 Receptors Are Required for Normal Expression of Imprinted Genes”. Proc Natl Acad Sci U S A 111 (40): 14512-7.
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
Lu, Mingjian, Min Wan, Karla Leavens, Qingwei Chu, Bobby Monks, Sully Fernandez, Rexford Ahima, Kohjiro Ueki, Ronald Kahn, and Morris Birnbaum. 2012. “Insulin Regulates Liver Metabolism in Vivo in the Absence of Hepatic Akt and Foxo1”. Nat Med 18 (3): 388-95.
Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome
Ussar, Siegfried, Nicholas Griffin, Olivier Bezy, Shiho Fujisaka, Sara Vienberg, Samir Softic, Luxue Deng, Lynn Bry, Jeffrey Gordon, and Ronald Kahn. 2015. “Interactions Between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome”. Cell Metab 22 (3): 516-30.
Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance
Vernochet, Cecile, Arnaud Mourier, Olivier Bezy, Yazmin Macotela, Jeremie Boucher, Matthew Rardin, Ding An, et al. 2012. “Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice Against Obesity and Insulin Resistance”. Cell Metab 16 (6): 765-76.
Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD
Softic, Samir, Jeremie Boucher, Marie Solheim, Shiho Fujisaka, Max-Felix Haering, Erica Homan, Jonathon Winnay, Antonio Perez-Atayde, and Ronald Kahn. 2016. “Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD”. Diabetes 65 (8): 2187-200.
A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species
Xu, Cong, Mohammadsharif Tabebordbar, Salvatore Iovino, Christie Ciarlo, Jingxia Liu, Alessandra Castiglioni, Emily Price, et al. 2013. “A Zebrafish Embryo Culture System Defines Factors That Promote Vertebrate Myogenesis across Species”. Cell 155 (4): 909-21.
Research
The Kahn Lab is investigating the mechanism of insulin action and its alterations in insulin resistant states, including type 2 diabetes, obesity and metabolic syndrome. There are 3 major areas of research: 1) Insulin action and insulin resistance. In this area we have projects focusing on the...