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Stepwise Distributed Open Innovation Contests for Software Development: Acceleration of Genome-Wide Association Analysis

Publication: Journal Article

Hill, Andrew, Po-Ru Loh, Ragu Bharadwaj, Pascal Pons, Jingbo Shang, Eva Guinan, Karim Lakhani, Iain Kilty, and Scott Jelinsky. 2017. “Stepwise Distributed Open Innovation Contests for Software Development: Acceleration of Genome-Wide Association Analysis”. Gigascience 6 (5): 1-10.

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Publication: Journal Article

Day, Felix, Deborah Thompson, Hannes Helgason, Daniel Chasman, Hilary Finucane, Patrick Sulem, Katherine Ruth, et al. 2017. “Genomic Analyses Identify Hundreds of Variants Associated With Age at Menarche and Support a Role for Puberty Timing in Cancer Risk”. Nat Genet 49 (6): 834-41.

Stepping to infinity along Gaussian primes

Publication: Journal Article

Loh, Po-Ru. 2007. “Stepping to Infinity Along Gaussian Primes”. American Mathematical Monthly 114 (2): 142–151.

Multiethnic polygenic risk scores improve risk prediction in diverse populations

Publication: Journal Article

Márquez-Luna, Carla, Po-Ru Loh, and Alkes Price. 2017. “Multiethnic Polygenic Risk Scores Improve Risk Prediction in Diverse Populations”. Genet Epidemiol 41 (8): 811-23.

Making polygons by simple folds and one straight cut

Publication: Journal Article

Demaine, Erik, Martin Demaine, Andrea Hawksley, Hiro Ito, Po-Ru Loh, Shelly Manber, and Omari Stephens. 2011. “Making Polygons by Simple Folds and One Straight Cut”. Computational Geometry, Graphs and Applications, 27–43.

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Publication: Journal Article

Willems, Sara, Daniel Wright, Felix Day, Katerina Trajanoska, Peter Joshi, John Morris, Amy Matteini, et al. 2017. “Large-Scale GWAS Identifies Multiple Loci for Hand Grip Strength Providing Biological Insights into Muscular Fitness”. Nat Commun 8: 16015.

Po-Ru Loh

Person: Associate Professor, Harvard Medical School, Associate Member, Broad Institute of MIT and Harvard

Po-Ru completed a B.S. in Mathematics at Caltech and a Ph.D. in Applied Mathematics at MIT with Bonnie Berger. He then trained as a postdoc in Statistical Genetics with Alkes Price at the Harvard T.H. Chan School of Public Health. Once upon a time, Po-Ru competed in math olympiads, the Putnam...

Heritability of Atrial Fibrillation

Publication: Journal Article

Weng, Lu-Chen, Seung Hoan Choi, Derek Klarin, Gustav Smith, Po-Ru Loh, Mark Chaffin, Carolina Roselli, et al. 2017. “Heritability of Atrial Fibrillation”. Circ Cardiovasc Genet 10 (6).

Burroughs Wellcome Fund CASI grant

News: May 18, 2017

Po-Ru Loh has been awarded a Burroughs Wellcome Fund Career Award at the Scientific Interface for his research applying statistical phasing methods to detect chromosomal abnormalitiies in blood DNA.

New preprint (Loh et al.): Mixed model association for biobank-scale data sets

News: September 27, 2017

Biobank-based genome-wide association studies are enabling exciting insights in complex trait genetics, but much uncertainty remains over best practices for optimizing statistical power and computational efficiency in GWAS while controlling confounders. Here, we introduce a much faster version of...