The emerging genetic architecture of type 2 diabetes
Doria, Alessandro, Mary-Elizabeth Patti, and Ronald Kahn. 2008. “The Emerging Genetic Architecture of Type 2 Diabetes”. Cell Metab 8 (3): 186-200.
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Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells
Rajala, Ammaji, Masaki Tanito, Yun Le, Ronald Kahn, and Raju Rajala. 2008. “Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells”. J Biol Chem 283 (28): 19781-92.
Central insulin action regulates peripheral glucose and fat metabolism in mice
Koch, Linda, Thomas Wunderlich, Jost Seibler, Christine Könner, Brigitte Hampel, Sigrid Irlenbusch, Georg Brabant, Ronald Kahn, Frieder Schwenk, and Jens Brüning. 2008. “Central Insulin Action Regulates Peripheral Glucose and Fat Metabolism in Mice”. J Clin Invest 118 (6): 2132-47.
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis
Biddinger, Sudha, Antonio Hernandez-Ono, Christian Rask-Madsen, Joel Haas, José Alemán, Ryo Suzuki, Erez Scapa, et al. 2008. “Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis”. Cell Metab 7 (2): 125-34.
Rad GTPase deficiency leads to cardiac hypertrophy
Chang, Lin, Jifeng Zhang, Yu-Hua Tseng, Chang-Qing Xie, Jacob Ilany, Jens Brüning, Zhongcui Sun, et al. 2007. “Rad GTPase Deficiency Leads to Cardiac Hypertrophy”. Circulation 116 (25): 2976-83.
Tumstatin, an endothelial cell-specific inhibitor of protein synthesis
Maeshima, Yohei, Akulapalli Sudhakar, Julie Lively, Kohjiro Ueki, Surender Kharbanda, Ronald Kahn, Nahum Sonenberg, Richard Hynes, and Raghu Kalluri. 2002. “Tumstatin, an Endothelial Cell-Specific Inhibitor of Protein Synthesis”. Science 295 (5552): 140-3.
Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase
Ueki, Kohjiro, Claudine Yballe, Saskia Brachmann, David Vicent, John Watt, Ronald Kahn, and Lewis Cantley. 2002. “Increased Insulin Sensitivity in Mice Lacking P85beta Subunit of Phosphoinositide 3-Kinase”. Proc Natl Acad Sci U S A 99 (1): 419-24.
Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes
Fasshauer, Klein, Kriauciunas, Ueki, Benito, and Kahn. 2001. “Essential Role of Insulin Receptor Substrate 1 in Differentiation of Brown Adipocytes”. Mol Cell Biol 21 (1): 319-29.
Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling
Tsuruzoe, Emkey, Kriauciunas, Ueki, and Kahn. 2001. “Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling”. Mol Cell Biol 21 (1): 26-38.
Unraveling the mechanism of action of thiazolidinediones
Kahn, Chen, and Cohen. 2000. “Unraveling the Mechanism of Action of Thiazolidinediones”. J Clin Invest 106 (11): 1305-7.