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Highlights from the 2018 ARVO Annual Meeting

News: May 17, 2018

The Department of Ophthalmology was, once again, well represented at this year’s Association for Research and Vision in Ophthalmology (ARVO) Imaging in the Eye Conference and Annual Meeting, held April 28 through May 3 in Honolulu, Hawaii. More than 145 faculty and trainees participated as course...

Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha

Publication: Journal Article

Almind, Katrine, Laurent Delahaye, Torben Hansen, Emmanuel Van Obberghen, Oluf Pedersen, and Ronald Kahn. 2002. “Characterization of the Met326Ile Variant of Phosphatidylinositol 3-Kinase P85alpha”. Proc Natl Acad Sci U S A 99 (4): 2124-8.

Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells

Publication: Journal Article

Roper, Michael, Wei-jun Qian, Bei Zhang, Rohit Kulkarni, Ronald Kahn, and Robert Kennedy. 2002. “Effect of the Insulin Mimetic L-783,281 on Intracellular Ca2+ and Insulin Secretion from Pancreatic Beta-Cells”. Diabetes 51 Suppl 1: S43-9.

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival

Publication: Journal Article

Ueki, Kohjiro, David Fruman, Saskia Brachmann, Yu-Hua Tseng, Lewis Cantley, and Ronald Kahn. 2002. “Molecular Balance Between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival”. Mol Cell Biol 22 (3): 965-77.

Absence of insulin receptor substrate-1 expression does not alter GLUT1 or GLUT4 abundance or contraction-stimulated glucose uptake by mouse skeletal muscle

Publication: Journal Article

Dumke, Wetter, Arias, Kahn, and Cartee. 2001. “Absence of Insulin Receptor Substrate-1 Expression Does Not Alter GLUT1 or GLUT4 Abundance or Contraction-Stimulated Glucose Uptake by Mouse Skeletal Muscle”. Horm Metab Res 33 (12): 696-700.

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance

Publication: Journal Article

Guerra, Navarro, Valverde, Arribas, Brüning, Kozak, Kahn, and Benito. 2001. “Brown Adipose Tissue-Specific Insulin Receptor Knockout Shows Diabetic Phenotype Without Insulin Resistance”. J Clin Invest 108 (8): 1205-13.

Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

Publication: Journal Article

Leibiger, Leibiger, Moede, Kemper, Kulkarni, Kahn, Vargas, and Berggren. 2001. “Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic Beta Cells”. Mol Cell 7 (3): 559-70.

Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4

Publication: Journal Article

Kim, Zisman, Fillmore, Peroni, Kotani, Perret, Zong, et al. 2001. “Glucose Toxicity and the Development of Diabetes in Mice With Muscle-Specific Inactivation of GLUT4”. J Clin Invest 108 (1): 153-60.

Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23

Publication: Journal Article

Tseng, Vicent, J. Zhu, Niu, Adeyinka, Moyers, Watson, and Kahn. 2001. “Regulation of Growth and Tumorigenicity of Breast Cancer Cells by the Low Molecular Weight GTPase Rad and Nm23”. Cancer Res 61 (5): 2071-9.

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes

Publication: Journal Article

Mauvais-Jarvis, Virkamaki, Michael, Winnay, Zisman, Kulkarni, and Kahn. 2000. “A Model to Explore the Interaction Between Muscle Insulin Resistance and Beta-Cell Dysfunction in the Development of Type 2 Diabetes”. Diabetes 49 (12): 2126-34.