[B22-D-arginine]insulin: synthesis and biological properties
Knorr, Danho, Büllesbach, Gattner, Zahn, King, and Kahn. 1982. “[B22-D-Arginine]insulin: Synthesis and Biological Properties”. Hoppe Seylers Z Physiol Chem 363 (12): 1449-60.
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Subpopulations of antibodies directed against evolutionarily conserved regions of the insulin molecule in insulin-treated patients
Karlsson, Harrison, Kahn, Itin, and Roth. 1982. “Subpopulations of Antibodies Directed Against Evolutionarily Conserved Regions of the Insulin Molecule in Insulin-Treated Patients”. Diabetologia 23 (6): 488-93.
Synthesis and characterization of molecular hybrids of insulin and insulin-like growth factor I. The role of the A-chain extension peptide
King, Kahn, Samuels, Danho, Büllesbach, and Gattner. 1982. “Synthesis and Characterization of Molecular Hybrids of Insulin and Insulin-Like Growth Factor I. The Role of the A-Chain Extension Peptide”. J Biol Chem 257 (18): 10869-73.
Interactions between the receptors for insulin and the insulin-like growth factors on adipocytes
King, Rechler, and Kahn. 1982. “Interactions Between the Receptors for Insulin and the Insulin-Like Growth Factors on Adipocytes”. J Biol Chem 257 (17): 10001-6.
Mentorship and Alumni
Over my 30+ year scientific career, a major focus of the laboratory has been mentoring of students and fellows in the laboratory. At present, there are usually between 12-14 post-doctoral fellows, 1-2 students, and 1 visiting scientist in the laboratory. In total, about 150 fellows have trained in...
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
Mauvais-Jarvis, Franck, Kohjiro Ueki, David Fruman, Michael Hirshman, Kei Sakamoto, Laurie Goodyear, Matteo Iannacone, Domenico Accili, Lewis Cantley, and Ronald Kahn. 2002. “Reduced Expression of the Murine P85alpha Subunit of Phosphoinositide 3-Kinase Improves Insulin Signaling and Ameliorates Diabetes”. J Clin Invest 109 (1): 141-9.
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Yoon, Puigserver, Chen, Donovan, Wu, Rhee, Adelmant, et al. 2001. “Control of Hepatic Gluconeogenesis through the Transcriptional Coactivator PGC-1”. Nature 413 (6852): 131-8.
Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13
Magré, Delépine, Khallouf, Gedde-Dahl, Van Maldergem, Sobel, Papp, et al. 2001. “Identification of the Gene Altered in Berardinelli-Seip Congenital Lipodystrophy on Chromosome 11q13”. Nat Genet 28 (4): 365-70.
Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells
Leibiger, Leibiger, Moede, Kemper, Kulkarni, Kahn, Vargas, and Berggren. 2001. “Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic Beta Cells”. Mol Cell 7 (3): 559-70.
Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis
Valverde, Mur, Pons, Alvarez, White, Kahn, and Benito. 2001. “Association of Insulin Receptor Substrate 1 (IRS-1) Y895 With Grb-2 Mediates the Insulin Signaling Involved in IRS-1-Deficient Brown Adipocyte Mitogenesis”. Mol Cell Biol 21 (7): 2269-80.