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Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

Publication: Journal Article

Der, Suryawanshi, Morozov, Kustagi, Goilav, Ranabathou, Izmirly, et al. 2019. “Tubular Cell and Keratinocyte Single-Cell Transcriptomics Applied to Lupus Nephritis Reveal Type I IFN and Fibrosis Relevant Pathways”. Nature Immunology 20 (7): 915-27.

Joyce Kang

Person: Harvard Medical School MD-PhD Student

I’m an MD/PhD student (MD though the Harvard/MIT HST program and PhD in Bioinformatics & Integrative Genomics). I joined the Raychaudhuri Lab in the summer of 2019 and am currently working on developing computational methods to efficiently map single-cell RNA-seq datasets against multi-million-cell...

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue

Publication: Journal Article

Donlin, Laura T., Deepak A. Rao, Kevin Wei, Kamil Slowikowski, Mandy J. McGeachy, Jason D. Turner, Nida Meednu, et al. 2018. “Methods for High-Dimensonal Analysis of Cells Dissociated from Cyropreserved Synovial Tissue”. Arthritis Research & Therapy 20 (1): 139.

Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis

Publication: Journal Article

Cortes, Adrian, Dafna Gladman, Soumya Raychaudhuri, Jing Cui, Lawrie Wheeler, and Matthew A. Brown. 2018. “Imputation-Based Analysis of MICA Alleles in the Susceptibility to Ankylosing Spondylitis”. Annals of the Rheumatic Diseases 77 (11): 1691-92.

The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype

Publication: Journal Article

Stanaway, Ian B., Taryn O. Hall, Elisabeth A. Rosenthal, Melody Palmer, Vivek Naranbhai, Rachel Knevel, Bahram Namjou‐Khales, et al. 2019. “The EMERGE Genotype Set of 83,717 Subjects Imputed to ~40 million Variants Genome Wide and Association With the Herpes Zoster Medical Record Phenotype”. Genetic Epidemiology 43 (1): 63-81.

Lymphocyte innateness is defined by underlying transcriptional states reflecting a balance between proliferation and effector functions

Publication: Journal Article

Gutierrez-Arcelus, Maria, Nikola C. Teslovich, Alex Mola, R. B. Polidoro, A. Nathan, H. Kim, Susan K. Hannes, et al. 2019. “Lymphocyte Innateness Is Defined by Underlying Transcriptional States Reflecting a Balance Between Proliferation and Effector Functions”. Nature Communications 10 (1): 687.

Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases.

Publication: Journal Article

Hinks, Anne, John Bowes, Joanna E. Cobb, Hannah C. Ainsworth, Miranda C. Marlon, M. E. Comeau, Marc Sudman, et al. 2017. “Fine-Mapping the MHC Locus in Juvenile Idiopathic Arthritis (JIA) Reveals Genetic Heterogeneity Corresponding to Distinct Adult Inflammatory Arthritic Diseases.”. Annals of Rheumatic Diseases 76 (4): 765-72.

Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.

Publication: Journal Article

Scally, Stephen, Soi Cheng Law, Yi Tian Ting, Jurgen Van Heemst, Jeremy Sokolove, Aaron J. Deutsch, E. Bridie Clemens, et al. 2017. “Molecular Basis for Increased Susceptibility of Indigenous North Americans to Seropositive Rheumatoid Arthritis.”. Annals of Rheumatic Diseases 76 (11): 1915-23.

Review: Genetics and the Classification of Arthritis in Adults and Children.

Publication: Journal Article

Nigrovic, Peter A., Soumya Raychaudhuri, and Susan D. Thompson. 2018. “Review: Genetics and the Classification of Arthritis in Adults and Children.”. Arthritis Rheumatology 7 (1): 7-17.

Macrophages tailor their function according to the signals found in tissue microenvironments, assuming a wide spectrum of phenotypes. A detailed understanding of macrophage phenotypes in human tissues is limited. Using single-cell RNA sequencing, we defin

Publication: Journal Article

Kuo, Ding, IS Cohn, Zhang, Wei, DA Rao, Rozo, et al. 2019. “Macrophages Tailor Their Function According to the Signals Found in Tissue Microenvironments, Assuming a Wide Spectrum of Phenotypes. A Detailed Understanding of Macrophage Phenotypes in Human Tissues Is Limited. Using Single-Cell RNA Sequencing, We Defin”. Science Translational Medicine 11 (491): eaau8587.