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Scientific Core

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The Next-Generation Clinical Research and Data Science Core monitors clinical and research activities of all Center sites, including Massachusetts Eye and Ear Infirmary (MEE), Massachusetts General Hospital (MGH), University of Utah (UofU), and University of California San Francisco (UCSF). The Core...

Project 3: Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor

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Nicole Buie, B.S.

Person: Research Assistant

Nicole graduated from Loyola University Chicago with a B.S. degree in Cognitive Behavioral Neuroscience and Psychology. As an undergraduate student, she worked in the lab of Dr. Stephen Steidl. There, she investigated the neural circuitry of reward using pharmacological interventions and...

Could a Less Complex Larynx Have Enabled Speech in Humans?

News: August 11, 2022

The Scientist A paper argues that the evolutionary loss of a thin vocal membrane in the larynx may have facilitated oral communication. Dr. Kristina Simonyan is quoted. Read the full article here.

Sodium Oxybate: Novel Oral Drug for Laryngeal Dystonia and Voice Tremor

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The effect of sodium oxybate (Xyrem ®) in a patient with laryngeal dystonia and voice tremor before (A) and after (B) drug intake (S imonyan K and Frucht SJ, Tremor Other Hyperkin Dis, 2013 ) Current treatment of laryngeal dystonia (LD) is limited to the temporary management of voice symptoms with...

Publications

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Graph-theoretical insights into the effects of aging on the speech production network

Publication: Journal Article

Schill, Jana, Kristina Simonyan, Maximilian Corsten, Christian Mathys, Christiane Thiel, and Karsten Witt. 2022. “Graph-Theoretical Insights into the Effects of Aging on the Speech Production Network”. Cerebral Cortex May 19.

Brain-computer interfaces for treatment of focal dystonia

Publication: Journal Article

Simonyan, Kristina, Stefan Ehrlich, Richard Andersen, Jonathan Brumberg, Frank Guenther, Mark Hallett, Matthew Howard, et al. 2022. “Brain-Computer Interfaces for Treatment of Focal Dystonia”. Movement Disorders 37 (9): 1798-1802.

DystoniaBoTXNet: Novel Neural Network Biomarker of Botulinum Toxin Efficacy in Isolated Dystonia

Publication: Journal Article

Yao, Dongren, Lena O’Flynn, and Kristina Simonyan. 2022. “DystoniaBoTXNet: Novel Neural Network Biomarker of Botulinum Toxin Efficacy in Isolated Dystonia”. Annals of Neurology.

Mikayla Day, B.A.

Person: Research Assistant

Mikayla received her Bachelor's degree in Psychology with a concentration in Neuroscience from the Pennsylvania State University. During her time as an undergraduate, she worked in Dr. Jenae Neiderhiser's Gene X Environment Interplay Throughout the Lifespan Lab where she collected and managed data...