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A rare human variant that disrupts GPR10 signalling causes weight gain in mice.

Publication: Journal Article

Talbot, Fleur, Claire H Feetham, Jacek Mokrosiński, Katherine Lawler, Julia M Keogh, Elana Henning, Edson Mendes de Oliveira, et al. 2023. “A Rare Human Variant That Disrupts GPR10 Signalling Causes Weight Gain in Mice.”. Nature Communications 14 (1): 1450.

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Blog: April 19, 2023

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Meet the Researchers: Silvia Minardi, PhD

News: June 02, 2020

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The genetic structure of the Turkish population reveals high levels of variation and admixture.

Publication: Journal Article

Kars, Ece, Nazlı Başak, Emre Onat, Kaya Bilguvar, Jungmin Choi, Yuval Itan, Caner Çağlar, et al. 2021. “The Genetic Structure of the Turkish Population Reveals High Levels of Variation and Admixture.”. Proceedings of the National Academy of Sciences of the United States of America 118 (36).

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.

Publication: Journal Article

Brouwers, Bas, Edson Mendes de Oliveira, Maria Marti-Solano, Fabiola B F Monteiro, Suli-Anne Laurin, Julia M Keogh, Elana Henning, et al. 2021. “Human MC4R Variants Affect Endocytosis, Trafficking and Dimerization Revealing Multiple Cellular Mechanisms Involved in Weight Regulation.”. Cell Reports 34 (12): 108862.

Exerkines in health, resilience and disease.

Publication: Journal Article

Chow, Lisa S, Robert E Gerszten, Joan M Taylor, Bente K Pedersen, Henriette van Praag, Scott Trappe, Mark A Febbraio, et al. 2022. “Exerkines in Health, Resilience and Disease.”. Nature Reviews. Endocrinology 18 (5): 273-89.