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We found that lin-4 mutants have short lifespans, while lin-4 over-expression extends lifespan and slows aging [1]. This was the first report of a role for miRNAs in regulating lifespan, and led to an intense study in my lab of roles for miRNAs in aging. Initially, we performed high throughput...

NIH/NIA- JUVENILE MICRORNAS PROMOTING HEALTHIER ADULT AGING: We showed first that microRNAs control aging and that they act upstream of insulin and insulin-like receptor (IIS) and other known longevity pathways. In this proposal, we propose to use discovery-based and hypothesis-based methods that we...