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Genome-wide association analysis of composite sleep health scores in 413,904 individuals.

Publication: Journal Article

Goodman, Matthew O, Tariq Faquih, Valentina Paz, Pavithra Nagarajan, Jacqueline M Lane, Brian Spitzer, Matthew Maher, et al. 2024. “Genome-Wide Association Analysis of Composite Sleep Health Scores in 413,904 Individuals.”. MedRxiv : The Preprint Server for Health Sciences.

Discovery of selective Orai channel blockers bearing an indazole or a pyrazole scaffold

Publication: Journal Article

Liardo, Elisa, Anh-Tuan Pham, Amanda F. Ghilardi, Tetyana Zhelay, Kalina Szteyn, Naga Lakshmi Gandi, Anil Ekkati, Steffi Koerner, Ashot Kozak, and Lijun Sun. 2024. “Discovery of Selective Orai Channel Blockers Bearing an Indazole or a Pyrazole Scaffold”. European Journal of Medicinal Chemistry 278: 116805.

Parkinson’s may begin in the gut, study says, adding to growing evidence

News: September 05, 2024

A new study from the BIDMC Institute for Gut-Brain Research adds to a growing body of evidence that Parkinson’s disease, long believed to have its origins in the brain, may begin in the gut. Gastrointestinal problems are common in patients with neurodegenerative disorders, to the point where a...

Welcome Cecilia and Perla!

News: August 12, 2024

We are honored to welcome Cecilia Cuilty Villarreal and Perla Alpizar Chacon who are joining us from Tecnológico de Monterrey for their undergraduate theses. We're excited to hear their ideas and collaborate with them on the development of their projects.

Employee Appreciation Day!

News: July 19, 2024

BIDMC hosted its employee appreciation day this past week, where the team enjoyed a team lunch, ice cream, and some summer sun!

Blood metabolites predicting mild cognitive impairment in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).

Publication: Journal Article

He, Shan, Einat Granot-Hershkovitz, Ying Zhang, Jan Bressler, Wassim Tarraf, Bing Yu, Tianyi Huang, et al. 2022. “Blood Metabolites Predicting Mild Cognitive Impairment in the Study of Latinos-Investigation of Neurocognitive Aging (HCHS/SOL).”. Alzheimer’s & Dementia (Amsterdam, Netherlands) 14 (1): e12259.

Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study.

Publication: Journal Article

Wang, Heming, Nuzulul Kurniansyah, Brian E Cade, Matthew O Goodman, Han Chen, Daniel J Gottlieb, Sina A Gharib, et al. 2022. “Upregulated Heme Biosynthesis Increases Obstructive Sleep Apnea Severity: A Pathway-Based Mendelian Randomization Study.”. Scientific Reports 12 (1): 1472.

Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed program.

Publication: Journal Article

Khan, Alyna T, Stephanie M Gogarten, Caitlin P McHugh, Adrienne M Stilp, Tamar Sofer, Michael L Bowers, Quenna Wong, et al. 2022. “Recommendations on the Use and Reporting of Race, Ethnicity, and Ancestry in Genetic Research: Experiences from the NHLBI TOPMed Program.”. Cell Genomics 2 (8).

Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations.

Publication: Journal Article

Elgart, Michael, Genevieve Lyons, Santiago Romero-Brufau, Nuzulul Kurniansyah, Jennifer A Brody, Xiuqing Guo, Henry J Lin, et al. 2022. “Non-Linear Machine Learning Models Incorporating SNPs and PRS Improve Polygenic Prediction in Diverse Human Populations.”. Communications Biology 5 (1): 856.

Plasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition.

Publication: Journal Article

Granot-Hershkovitz, Einat, Shan He, Jan Bressler, Bing Yu, Wassim Tarraf, Casey M Rebholz, Jianwen Cai, et al. 2023. “Plasma Metabolites Associated With Cognitive Function across Race/Ethnicities Affirming the Importance of Healthy Nutrition.”. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association 19 (4): 1331-42.