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335 results found

NF-κB Blockade with Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants.

Publication: Journal Article

Morel, Katherine L, Anis A Hamid, John G Clohessy, Nicole Pandell, Leigh Ellis, and Christopher J Sweeney. 2021. “NF-κB Blockade With Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants.”. Molecular Cancer Research : MCR 19 (7): 1137-45.

Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors.

Publication: Journal Article

Chin, Tan-Min, Gandhi T K Boopathy, Ellen P S Man, John G Clohessy, Eva Csizmadia, Margaret P Quinlan, Thomas Putti, et al. 2020. “Targeting Microtubules Sensitizes Drug Resistant Lung Cancer Cells to Lysosomal Pathway Inhibitors.”. Theranostics 10 (6): 2727-43.

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.

Publication: Journal Article

Lee, Yu-Ru, Ming Chen, Jonathan D Lee, Jinfang Zhang, Shu-Yu Lin, Tian-Min Fu, Hao Chen, et al. 2019. “Reactivation of PTEN Tumor Suppressor for Cancer Treatment through Inhibition of a MYC-WWP1 Inhibitory Pathway.”. Science (New York, N.Y.) 364 (6441).

The Mouse Hospital and Its Integration in Ultra-Precision Approaches to Cancer Care.

Publication: Journal Article

Clohessy, John G, and Pier Paolo Pandolfi. 2018. “The Mouse Hospital and Its Integration in Ultra-Precision Approaches to Cancer Care.”. Frontiers in Oncology 8: 340.

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.

Publication: Journal Article

Chew, Chen Li, Andrea Lunardi, Federico Gulluni, Daniel T Ruan, Ming Chen, Leonardo Salmena, Michiya Nishino, et al. 2015. “In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.”. Cancer Discovery 5 (7): 740-51.

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.

Publication: Journal Article

Gonzalez-Billalabeitia, Enrique, Nina Seitzer, Su Jung Song, Min Sup Song, Akash Patnaik, Xue-Song Liu, Mirjam T Epping, et al. 2014. “Vulnerabilities of PTEN-TP53-Deficient Prostate Cancers to Compound PARP-PI3K Inhibition.”. Cancer Discovery 4 (8): 896-904.

Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment.

Publication: Journal Article

Sadow, Peter M, Carmen Priolo, Simona Nanni, Florian A Karreth, Mark Duquette, Roberta Martinelli, Amjad Husain, et al. 2014. “Role of BRAFV600E in the First Preclinical Model of Multifocal Infiltrating Myopericytoma Development and Microenvironment.”. Journal of the National Cancer Institute 106 (8).

Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis.

Publication: Journal Article

Clohessy, John G, Jianguo Zhuang, Jasper de Boer, Gabriel Gil-Gómez, and Hugh J M Brady. 2006. “Mcl-1 Interacts With Truncated Bid and Inhibits Its Induction of Cytochrome C Release and Its Role in Receptor-Mediated Apoptosis.”. The Journal of Biological Chemistry 281 (9): 5750-9.

Characterisation of Mcl-1 cleavage during apoptosis of haematopoietic cells.

Publication: Journal Article

Clohessy, John G, Jianguo Zhuang, and Hugh J M Brady. 2004. “Characterisation of Mcl-1 Cleavage During Apoptosis of Haematopoietic Cells.”. British Journal of Haematology 125 (5): 655-65.

Current funding

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1985-2025: NIDDK/NIH T32 DK07516 | B. Kahn – PI “Integrated Endocrine and Metabolic Research Training” 2012-2027: JPB Foundation | B. Kahn – PI “Characterization of a novel class of lipids involved in insulin sensitivity” 2016-2025: NIDDK/NIH R01 DK106210-01 | B. Kahn and A. Saghatelian – Multi-PIs...