2025 BIDMC Cores Science Day
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Dr. Somnath Bose publishes study identifying priorities of patients who survive an Intensive Care unit stay
Surviving ICU stay is often just the first step in a long road to recovery for most. The aftermath of critical illness is often challenging for survivors and their caregivers who bear the burden of post-intensive care syndrome (PICS). Unfortunately, there is very little investigation on how...
MicroRNA spatial profiling for assessing drug efficacy in BRCA1-related triple-negative breast tumors
Mohd, Omar N, Lin Wang, Brian R Sardella, David Jou, Gerburg M Wulf, Frank J Slack, Yujing J Heng, and Patrick S Doyle. 2026. “MicroRNA Spatial Profiling for Assessing Drug Efficacy in BRCA1-Related Triple-Negative Breast Tumors”. BioRxiv, 2026.01.12.698824.
Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGFβ1 Axis.
Prete, Alessandro, Agnes S Lo, Peter M Sadow, Swati S Bhasin, Zeus A Antonello, Danica M Vodopivec, Soumya Ullas, et al. 2018. “Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGFβ1 Axis.”. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 24 (23): 6078-97.
Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.
Duquette, Mark, Peter M Sadow, Amjad Husain, Jennifer N Sims, Zeus A Antonello, Andrew H Fischer, Chen Song, et al. 2015. “Metastasis-Associated MCL1 and P16 Copy Number Alterations Dictate Resistance to Vemurafenib in a BRAFV600E Patient-Derived Papillary Thyroid Carcinoma Preclinical Model.”. Oncotarget 6 (40): 42445-67.
Expression of angiogenic switch, cachexia and inflammation factors at the crossroad in undifferentiated thyroid carcinoma with BRAF(V600E).
Husain, Amjad, Nina Hu, Peter M Sadow, and Carmelo Nucera. 2016. “Expression of Angiogenic Switch, Cachexia and Inflammation Factors at the Crossroad in Undifferentiated Thyroid Carcinoma With BRAF(V600E).”. Cancer Letters 380 (2): 577-85.
Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules.
Mekel, Michal, Carmelo Nucera, Richard A Hodin, and Sareh Parangi. 2010. “Surgical Implications of B-RafV600E Mutation in Fine-Needle Aspiration of Thyroid Nodules.”. American Journal of Surgery 200 (1): 136-43.
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.
Nucera, Carmelo, Alessandro Porrello, Zeus Andrea Antonello, Michal Mekel, Matthew A Nehs, Thomas J Giordano, Damien Gerald, et al. 2010. “B-Raf(V600E) and Thrombospondin-1 Promote Thyroid Cancer Progression.”. Proceedings of the National Academy of Sciences of the United States of America 107 (23): 10649-54.
The landscape of somatic copy-number alteration across human cancers.
Beroukhim, Rameen, Craig H Mermel, Dale Porter, Guo Wei, Soumya Raychaudhuri, Jerry Donovan, Jordi Barretina, et al. 2010. “The Landscape of Somatic Copy-Number Alteration across Human Cancers.”. Nature 463 (7283): 899-905.
ONi Aplo Scope
Please see the overview of the MassNano cores Aplo Scope. On this page you can find protocols and important training information.