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CalR
Go to CalR, a web application for indirect calorimetry analysis. The CalR project: There is a critical lack of standardization for indirect calorimetry experiments to measure body composition ( Corrigan et al eLife 2020, Banks et al Nature Metabolism 2025). Currently, the same dataset can produce...
Body Composition Systems
EchoMRI 3-in-1 Body Composition Analyzer Measures live mice up to 100g, tissue samples (including Zebrafish) of 10g, and biopsy samples up to 0.1g Measurements include lean mass, fat mass, and water mass 5 minutes per mouse No anesthesia required
Optogenetic stimulation of food intake
Optogenetic stimulation of Agrp neurons in ChR2-expressing mice was performed in the Promethion calorimeter, with food intake, metabolic rate, body temperature, and activity measured during the stimulation period.
About Us
Beth Israel Deaconess Medical Center and Harvard Medical School - The home of CalR Energy Balance Metabolic Core at BIDMC and Harvard Medical School is a facility designed for the measurement of energy intake, nutritional status, and energy expenditure in experimental mice. This facility consists of...
Equipment and Technologies
Our facilities were updated and re-launched as an institutional Energy Balance Metabolic Core in 2019 to continue the tradition of excellence in metabolic research. This included a bomb calorimeter and a thermal imaging camera. In 2020 we obtained a Promethion indirect calorimeter and DSI’s...
Thermogenesis: beta-adrenergic agonist activation
Male C57Bl/6J mice housed at thermoneutrality were administered the β-adrenergic agonist CL 316,243, and changes in oxygen consumption were continuously measured.
Induction of torpor
C57Bl/6J female mice were monitored for body temperature and metabolic rate during the dark photoperiod without food, with the blue trace representing a fed mouse and the red trace a fasted mouse exhibiting torpor (Hrvatin et al., Nature, 2020).
Quantitation rates of substrate oxidation in vivo using stable isotope tracing
In vivo stable isotope tracing with U-¹³C₆ D-mannitol and U-¹³C₆ D-glucose was conducted to enable ¹³CO₂ monitoring in the Promethion indirect calorimeter, with data plotted using CalR for conventional (blue) and commensal-depleted (red) mice (Vieira et al., in press).
Energy Balance Metabolic Core
Energy Balance Metabolic Core at BIDMC, measurement of energy intake, nutritional status, and energy expenditure in experimental mice