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A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases

Publication: Journal Article

Zhu, Zhaozhong, Phil Lee, Mark Chaffin, Wonil Chung, Po-Ru Loh, Quan Lu, David Christiani, and Liming Liang. 2018. “A Genome-Wide Cross-Trait Analysis from UK Biobank Highlights the Shared Genetic Architecture of Asthma and Allergic Diseases”. Nat Genet 50 (6): 857-64.

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

Publication: Journal Article

Finucane, Hilary, Yakir A Reshef, Verneri Anttila, Kamil Slowikowski, Alexander Gusev, Andrea Byrnes, Steven Gazal, et al. 2018. “Heritability Enrichment of Specifically Expressed Genes Identifies Disease-Relevant Tissues and Cell Types”. Nat Genet 50 (4): 621-29.

Talk on mosaic CNVs at Harvard Biostats / DBMI Big Data Seminar

News: April 30, 2018

Po-Ru Loh will be presenting work on mosaic CNVs in clonal hematopoiesis and brain development at the Harvard Biostatistics / HMS Department of Biomedical Informatics B3D Seminar on Mon 4/30.

Po-Ru Loh receives NIH Director's New Innovator Award

News: October 02, 2018

Po-Ru Loh has been selected for a 2018 NIH Director's New Innovator Award, which supports "unusually innovative research from early career investigators." The proposed project (" Revealing Somatic Genome Alterations and Their Clinical Sequelae: Ultrasensitive Computational Detection of Mosaic...

UK Biobank clonal hematopoiesis paper published in Nature

News: July 11, 2018

Our work on mosaic chromosomal alterations in the UK Biobank N=150K interim release has been published in Nature! This study used long-range haplotype phasing information to detect mosaicism in blood at very low clonal fractions (down to ~1%), producing an atlas of 8,342 mosaic events. The...

Mixed-model association for biobank-scale datasets

Publication: Journal Article

Loh, Po-Ru, Gleb Kichaev, Steven Gazal, Armin Schoech, and Alkes Price. 2018. “Mixed-Model Association for Biobank-Scale Datasets”. Nat Genet 50 (7): 906-8.

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Publication: Journal Article

Reshef, YA, Hilary Finucane, David Kelley, Alexander Gusev, Dylan Kotliar, Jacob Ulirsch, Farhad Hormozdiari, et al. 2018. “Detecting Genome-Wide Directional Effects of Transcription Factor Binding on Polygenic Disease Risk”. Nat Genet 50 (10): 1483-93.

Upcoming talks on phasing and mosaicism

News: October 08, 2018

Po-Ru Loh will be speaking about haplotype phasing and mosaic chromosomal alterations at 23andMe (Thu 10/11), ASHG 2018 (Wed 10/17, platform talk #17 at 9am), and Michigan (Tue 10/23).