Russo, Joshua W, and Steven P Balk. 2018. “Initiation and Evolution of Early Onset Prostate Cancer.”. Cancer Cell 34 (6): 874-76.
Abstract
In this issue of Cancer Cell, Gerhauser et al. analyze early-onset prostate cancers, showing roles for androgen receptor-driven rearrangements, an early APOBEC-driven mutational mechanism, and ESRP1 gene duplication. Through integration of whole-genome, transcriptome, and methylome data, they identify high-risk subgroups and develop an algorithm that may predict molecular evolution.