Plymate, Stephen R, Rupal S Bhatt, and Steven P Balk. 2015. “Taxane Resistance in Prostate Cancer Mediated by AR-Independent GATA2 Regulation of IGF2.”. Cancer Cell 27 (2): 158-9.
Abstract
GATA2 has been well-characterized as a critical pioneer transcription factor for androgen receptor (AR) in prostate cancer. In this issue of Cancer Cell, Vidal and colleagues identify increased GATA2 and its AR-independent transactivation of IGF2 as a mechanism that can mediate taxane resistance through activation of IGF1/insulin receptor signaling.