Research

sc

DAMPs in organ injury, fibrosis and cancer.

col

Extracellular matrix regulators in cancer and fibrosis.

mac

Macrophage biology in liver disease and cancer. 

Recent Publications

  1. Seika P, Janikova M, Asokan S, Janovicova L, Csizmadia E, O’Connell M, Robson SC, Glickman J, Wegiel B.  Free heme exacerbates colonic injury induced by anti-cancer therapy. Front Immunol, 2023 Jun 5;14:1184105, PMID: 37342339, PMCID: PMC10277564
  2. Canesin G, Feldbrügge L, Wei G, Janovicova L, Janikova M, Csizmadia E, Ariffin J, Hedblom A, Herbert ZT, Robson SC, Celec P, Swanson KD, Nasser I, Popov YV, Wegiel B. Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells. iScience. 2022 Aug 20;25(9):104983. PMID: PMID: 36093061 
  3. Canesin G, Di Ruscio A, Li M, Ummarino S, Hedblom A, Choudhury R, Krzyzanowska A, Csizmadia E, Palominos M, Stiehm A, Ebralidze A, Chen SY, Bassal MA, Zhao P, Tolosano E, Hurley L, Bjartell A, Tenen DG, Wegiel B. Scavenging of labile heme by hemopexin is a key checkpoint in cancer growth and metastases. Cell Rep. 2020 Sep 22;32(12):108181 (on a cover of September issue); PMID: 32966797; PMCID: PMC7551404.