Congratulations to Winnie Zhang—her paper "Transcriptional and epigenomic analysis of insulin sensitivity in human adipocytes” is out in Cell Reports. (https://www.cell.com/cell-reports/fulltext/S2211-1247(26)01120-4). This work profiled transcriptional and epigenetic (H3K27ac) differences in isolated human adipocytes from subjects with extremes of insulin sensitivity. Winnie found a large number of genomic regions that were differentially enriched between insulin sensitive and resistant subjects. She then used CRISPRi to validate some of these regulatory regions around the IRS1 gene in cultured human adipocytes and was able to nominate several key transcription factors. This project was done in collaboration with Linus Tsai and with Melina Claussnitzer at the Broad Institute.
