Frankie Heyward identifies IRF3 as a key mediator of the acute hunger-suppressing effects of leptin in AgRP neurons

Frankie Heyward’s paper was just published in Nature Communications. Frankie used cell-type specific profiling of gene expression and chromatin state in AgRP neurons to predict novel transcriptional mediators of leptin action. Surprisingly, his data suggested that IRF3 might work downstream of leptin, and functional studies proved this to be true. This important work illuminates how leptin induces satiety, and also expands the known metabolic repertoire of IRF3. Congratulations, Frankie!