Please check out the new paper from the Rosen lab (working in collaboration with Randy Seeley’s group at the University of Michigan) about changes in adipose tissue after two different weight loss strategies in mice. Margo Emont compared white adipose tissue from obese mice that received either vertical sleeve gastrectomy (VSG) or semaglutide. Some important changes in gene expression and cellular composition were conserved across weight loss interventions, while others were specific to either semaglutide or VSG. Margo also found that some gene expression programs in adipocytes reverted to a chow-like state after weight loss, while others remained “locked” in the obese pattern. link
