Zhang, Wen Cai, and Frank J Slack. 2016. “ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity”. Cell Stem Cell 19 (2): 141-42.
Leukemic stem cells (LSCs) drive progression of chronic myeloid leukemia (CML) and tyrosine kinase inhibitor resistance through poorly understood mechanisms. Now in Cell Stem Cell, Zipeto et al. (2016) show targeting the RNA editing enzyme ADAR1 restores expression of let-7 and efficiently kills LSCs, providing an innovative therapeutic target in CML.